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The secret is well and truly out for Bulgaria. With the cheapest property prices in Europe, and a ridiculously low cost of living, people are

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

buying Bulgarian properties in their droves.

Traditionally, property investing has been for the well-heeled, and the well-connected. Exotic f

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

oreign climes, slick city centre apartments and bustling holiday hideaways have offered huge returns to the canny and knowledgeable investor.

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

Bulgaria has certainly bucked the trend, with property prices are for all of the above that are well within the reach of the average investor.

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

Seduced by the fantastic climate, a laid-back lifestyle and fast appreciating prices, returning holidaymakers have fuelled the price of prop

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

erty, in more traditional European resorts, for years. Unfortunately, the growth in prices has been so dramatic, as to push prices in favourit

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

es such as Spain and Portugal, to record highs that are way out of the reach of the average purchaser.

Bulgaria is a refreshing change. Liken

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ed to Spain, some 15 years ago, this Balkan jewel offers a variety of properties that will fit in see even the smallest budget. It boasts fant

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

astic coastlines, the longest ski season in Europe, dynamic and vibrant cities and truly breathtaking countryside. Even better, the prices are

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

60 to 80% cheaper than any of its more fashionable equivalents.

For those with a tiny budget, there are country cottages, with acres of land

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

studded with fruit trees for less than ?10,000. Slick city centre apartments can be acquired, with fantastic all year round rental potential,

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

for less than ?20,000. The Black Sea has temperatures higher than that of the Mediterranean on the Spanish coast during the summer months. The

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

re, studio apartments with fantastic sea views, can be bought for less than ?30,000. The mountains offer miles and miles of unspoilt, tree-lin

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ed ski runs. Even with guaranteed rental of 15%, studio apartments can be found in the popular resort of Pamporovo for less than ?25,000.

Pri

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ces have risen steadily by 20 to 30% over the last several years. They will be catapulted even higher early in 2007 with full entry into the E

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

U. To maximise their return, and to obtain the very best prices, the smart investors are putting their money into Bulgaria now. This country i

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

s set to be the European investment hotspot for the next several years, offering fantastic returns from the small-time investor and corporate

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

purchaser alike.

We have a huge portfolio to trouble all the investment opportunities currently available in Bulgaria. We also currently have

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

a full range of absurdly cheap investment properties in the countryside, with prices from under ?10,000. Also on offer are ski apartments wit

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

h guaranteed rental, the only coastal villas with full disabled access and even a ten- bedroom countryside mansion, with pool for just ?70,000

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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