Advice Pool - Computers and Technology

Flash your ATI video card BIOS.

You will need the following:

1. 1.44MB FDD (floppy)

2. FLASHROM utility copy

3. Compatible B

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

IOS file for your video card. (search the manufactures website for bios details)

4. Required Drivers. (check manufactures websi

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

e)

Alright now

First make an ATI BIOS flash boot disk.

-Bios flash operations for video must be performed in DOS.

-You will

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

need a DOS boot disk, you can obtain one if you do not already ahve one at bootdisk.com, download there dr DOS image file after

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

hat run the .exe file that comes with it. Which will create a clean DOS boot disk. (if any problems folow instruction son the we

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

site)

-If you need other ways of obtaining a boot disk just post in a related thread.

Now that you have a DOS boot disk, copy

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

the BIOS file you downloaded and the FLASHROM.exe file onto the disk.

Second
Make a backup of your ATI video card BIOS

M

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ke a backup of your current video card BIOS before flashing the bios, incase of problems. (better safe than sorry)

-boot your c

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

mputer with the boot flash-disk you had created in the first step.

-during the "A:\" prompt type "flashrom.exe -s 0 backup.rom"

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ENTER

-now the utlity FLASHROM will make a backup of your video's bios onto the bios flash disk (called backup.rom)

-Just in

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ase, if we have to go back to the original bios.

Third
Flash your ATI video card's bios

-at the A:\ prompt type the foll

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

wing to flash your video bios

-"flashbios -p 0 (name of new bios file you downloaded including the extention) hit ENTER (no b

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

rackets around the name of your new bios file)

-Flashrom will overwrite your odl bios with your new bios.

-if any errors ocure

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

do not restart; consult troubleshooting.

-if there is a pause in the procedure, for say the bios types do not match you may us

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

a "-f" switch to force the operation (force if certian the bios suits your video card)

Forcing the BIOS flash type:

During

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

the thrid section instead of typing -"flashbios -p 0 (name of new bios file you downloaded including the extention)

Type

-"fla

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

hrom -f -p 0 (name of new bios file you downloaded including the extention)

-If you had made it this far without any errors and

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

everything seems to have gone correctly, than restart your system.

-monitor the post screen for the video card info

-double ch

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

eck that your procedure worked and your bios has worked correctly.

-also watch to see if your OS boots correctly

-plz keep in

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ind that your new bios may need new up to date drivers.

Hooray! Congrats! You have successfully changed your video card's BIOS

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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