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Ken Lay's death at the age of 64 was shocking and was the ultimate blow to an individual whom accumulated great wealth and status. However, as usu

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

al, time wears everyone out and Lay was no match.

Mr. Lay of course is viewed as the "Enron scoundrel" responsible with others for bilking around

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

183 million dollars while overstating the value of the company. Naturally, shareholders were destroyed as the orgy of greed by "Mr. I'm-going-to-

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ive-forever-so-let-me-dip-in" went on and on. Typically, the fun came to an end as it always does. And what was left was devastation, filthy gree

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

d, bankruptcy, hate, anger, sadness. Lay was indicted, found guilty and was going to be sentenced to somewhere around 20 years. Not good, especial

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ly for someone of his age. Then he was taken out by a massive heart attack. Adios, Ken.

Lay, by all accounts, did not seem like the evil guy he i

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

portrayed to be by the media throughout his life. He donated money to causes, was a guy from very humble beginnings and became an undersecretary

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

for the US Department of the Interior. Nice stuff. But that greed thing came back to haunt him.

Perhaps the stress of his case did him in. It wou

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ld certainly make sense. Going from the "big man" to a jackass is a tough thing to handle. Facing many years in jail is a brutal thing to deal wit

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

no matter how calm anyone is. He had some heart disease but was considered a stable heart patient like a ton of people.

When notorious mob thug

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

John Gotti was given a life sentence( he later died of neck cancer) he was caught on tape saying he would give his "bleeping right arm for a plate

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

of linguini with clam sauce." He knew the enjoyment of the little things in life was over. All of the years living high no longer mattered becaus

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

it was now over for Gotti. The millions of ill-gotten loot, the women, the media frenzy, the fear he brought, etc. Goodbye. And all he wanted was

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

bleeping linguini with clam sauce in the end. What a huge lesson to be learned. Despite being a "big-shot," it was built on a house of cards...li

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ke all of us.

Ken Lay was an extremely intelligent man with hints of goodness and hints of brutal greed and evil. The evil took over in the end a

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

d he paid for it. In the final stages, he seemed like an aging, somewhat frail man; certainly no big corporate guy. The image was being taken down

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

little-by-little. Then again, it is always a bad thing to worship another human being, particularly one whom makes a lot of money.

Mr. Lay is no

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

w dead. Hopefully, good things come his way in the next life. Why would one want to wish bad things? What does that do for the person wishing it?

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e are all going to face it relatively soon so why spread the hate? Anyway, the total power of death over humanity and all living things is to be r

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

espected, and not some guy on the scene who made some money and went in the same exact path we all are headed. Money is no match for death...again

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Everyone makes budgeting mistakes. It can take several trial and error months to get it all right. Budgets are constantly evolving. You have to work hard to find one that works for you. But there are mistakes you can avoid.

There is an easy to remember investment formula called the rule of 72. It is an easy way to help you estimate how much time you will need in order to double your investment. For example, let’s say that you need to double your money in 8 years. Divide 72 by 8 and you get 9. This means that you would need to earn 9% on your investment in order for the money to double in 8 years. The more money you start with, the more you will have earned, of course.

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Advice Pool - Ken Lay and the Great Equalizer

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