Advice Pool - Relationships

Friendship isn't always easily described. The Eskimos, they say, have a hundred different words for snow. Unfortunately, the English langu

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

age isn't quite as innovative, so friendship remains more as a cherished feeling among all of us. In cartoons we see such friendship which

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

the characters share with true humane feelings. Legendary friendships among cartoon characters include-

1. Tom and Jerry:

Tom and Jerry

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

are the Academic award winning cat (Tom) and mouse (Jerry) team who formed the basis of a successful cartoon series .They share the perfe

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ct recipe of friendship in the ambivalence of loving and teasing each other. Tom is very quick-tempered and thin-skinned, while Jerry is

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ndependent and opportunistic. Though very energetic and determined, Tom is no match for Jerry's brains and wits .yet they compliment each

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

other like cheese and milk.

2. Archie and Jughead:

The red-headed 17-year old teenager has the unique bonding with his best friend Jug

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ead Jones, who has been his friend since they were kids. In spite of being a Casanova,Archie is always seen sharing his deepest secrets wi

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

th Jughead. When Jughead first came to Riverdale, he was in a bad mood and tended to dismiss Archie. But Archie, of good heart, tried to c

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

eer up Jughead; they became inseparable ever since. Often Jughead has to help Archie out from a tricky situation, which usually involves g

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

irls.

3. Chip 'n' Dale:

Chip 'n' Dale are two fictional, animated chipmunks created by Walt Disney. They are inseparable pair who togeth

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

er fight with odds,struggle for the affections of another chipmunk, Clarice, annoy Donald Duck and solve mysteries. Chip is the (slightly)

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

more intelligent one with the black nose, and Dale is the one with the red nose and gapped teeth.

4. Mowgli and Bagheera:

Mowgli,the fer

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

al child from Rudyard Kipling's The Jungle Book was unknown to the laws of the jungle. He befriends Bagheera who educates and trains him

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

o survive in the jungle. Mowgli is the most prominent fictional character having so many talking animal friends who remains in his thick a

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

nd thin.

5. Flintstones and Rubbles:

The friendly neighbors- Fred and Wilma Flintstones and Barmey and Betty Rubbles are comical instanc

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

s of people abiding “Love thy neighbor” theory. The quartet hold each others hand in their highs and lows,while the husbands are the best

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

of friends . Fred,the henpecked one is stupid and most of the times ends up in trouble and Barmey ,the smarter one rescues his best friend

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

in each occasion.

Whether we have a Tom or a Barmey as friends,they are always special people. We can't pick our family, But our friends

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

can be as diverse and infinite as the stars in the sky. Our friends, in a very real sense, reflect the choices we make in life-good or bad

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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