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Sovereignty of the Falkland Islands had long been a point of dispute between Britain and Argentina. Events came to a head in 1982, when planned cut-back

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

s to the British Royal Navy convinced Argentina's ruling military junta that Britain no longer had the will or capability to defend the islands. The Fal

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

lands War, fought over these remote South Atlantic islands were the result.

Here are 13 decisive points in the conflict.

1. South Georgia (19th March

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

1982) - A group of Argentines, ostensibly on a scrap metal salvage mission, land on South Georgia and raise the Argentine flag.

2. Operacion Azul (2nd

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

pril 1982) - The Argentine navy lands a military force in the Falklands Islands proper, overwhelming the tiny British garrison of Royal Marines.

3. Dis

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

patch of the Task Force (3rd April 1982) - First Sea Lord, Sir Henry Leach, convinces Prime Minister Margaret Thatcher to send a naval task force with t

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e words, "because if we don't do that, in a few months we will be living in a different country whose word will for little!"

4. South Georgia (25th Apr

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

il 1982) - British Special Forces and Royal Marines recapture South Georgia. The Argentine submarine Santa Fe is crippled during the fighting.

5. Opera

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ion Black Buck (1st May 1982) - A Royal Air Force Vulcan bombs the Port Stanley airfield runway, denying use of the airfield to Argentine fast jets.

6.

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

General Belgrano (2nd May 1982) - The Argentine cruiser ARA General Belgrano is sank by the Royal Navy nuclear submarine, HMS Conqueror. The Argentine

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

avy withdraws to port and plays no further part in the war.

7. Sheffield (4th May 1982) - The Argentine airforce sinks the Royal Navy's HMS Sheffield u

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

sing an Exocet missile. It is the first of many British naval losses to Argentine air attack.

8. Pebble Island (14th to 15th May 1982) - British Specia

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

Forces raid the Argentine airbase at Pebble Island, destroying 11 Argentine aircraft.

9. San Carlos (23rd May 1982) - British troops land at San Carlo

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

s Water. Although, British ships come under severe Argentine air attack in "bomb alley", the Argentine's are unable to dislodge the British bridgehead.

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

10. Goose Green (27th to 28th May 1982) - British troops defeat Argentine forces defending the settlement at Goose Green in the first major land battle

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

of the war.

11. Bluff Cove (8th June 1982) - British troops landing from the RFA Sir Galahad and Sir Tristram at Bluff Cove, come under Argentine air

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ttack and suffer horrific casualties. However, even these losses are unable to stop the British advance on the ground.

12. Mount Longdown, Two Sisters

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

and Mount Harriet (11th to 12th June 1982) - British troops capture these three peaks in bitter fighting with Argentine ground forces.

13. Mount Tumble

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

own and Wireless Ridge (13th to 14th June 1982) - British troops capture these peaks which overlook Port Stanley in the last major land battle of the wa

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

r. Argentine forces in Port Stanley begin to raise white flags, and a surrender of all Argentine forces in the Falkland Islands is negotiated soon after

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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