Advice Pool - Reference and Education

Premonition or intuitive knowing refers to an experience when future events are foreseen. The phenomenon of premonit

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ion is characterized by sensations such as nervousness, anxiety, uneasiness, and a vague feeling of disquiet or unea

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

e which suggests an impending disaster. Visual or auditory information is also commonly reported in cases of premoni

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ion. The peculiar sensation seems to occur prior to disasters, accidents, deaths and other traumatic and emotionally

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

energized events. Premonitions can also come in the form of dreams.

Premonitions seem to be sensory oriented, mean

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ng that they are dominated by a sense of physical disquiet, anxiety, or stress that is without an easily discernible

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

source or readily apparent reason. It is an unexplainable and somewhat indescribable feeling that something is about

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

to happen.

Prophecy, in a broader sense is the prediction of future events. Prophecy is a general term for future

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

vents presented as the revelation of divine will. While premonitions deal with an apparent sensory foreknowledge of

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

he future which seems to be generated internally, prophecy is the foretelling of future events by an external or div

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ne force.

What is the ultimate significance of premonition and prophecy? Premonitions, more so than any other paran

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ormal phenomena telling us that our notions of the nature of the universe are misguided. Premonitions are completely

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

at odds with the present status of scientific thought. In essence premonition provides an effect before a cause

Un

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

er the rigid doctrine of scientific scrutiny such a scenario is 'impossible' and must not be true. Of course several

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ideas and objects that have been 'impossible' in the past have been later proven to exist. It was once 'impossible'

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

that the earth should orbit the sun, or that the earth was not flat. Today physicists are discussing the probability

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

of the existence of parallel universes, a subject once only the province of mystics and new age crack pots is now th

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

e topic of the best scientific minds.

Premonition and prophecy should not be casually dismissed by the scientific c

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

mmunity regardless of the conundrums created by their very existence. The phenomenon of foreknowing poses a challeng

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

to science that has not been met, but which promises a vastly greater understanding of the workings of the universe

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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