Advice Pool - Health and Fitness

It is really alarming! Heart attacks are causing a lot of deaths in the United States! In fact, heart attacks are among the leading causes of deaths in the country with nearly

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

half a million lives being claimed by this disease each and every year.

Let us take a closer look at how this disease develops.

A heart attack usually occurs when an artery s

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

pplying blood to the heart is obstructed by the formation of fatty plaques. Among the most common precursors of this untoward event are a high blood cholesterol level, atherosc

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

erosis, old age and an unhealthy lifestyle. While it is true that males are more susceptible to heart attacks, a woman’s chances of suffering from this fate increases as she re

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ches her post-menopausal years.

Now that you know the connection between your cholesterol level and the risk of developing cardiovascular diseases, one would guess you will be

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ore than willing to do something about it. Listed below are some of the recommended dietary changes that may help keep your blood cholesterol level in check and keep your heart

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

as healthy as possible.

Shy away from saturated fats. Eating too much saturated fat is the number one cause of high blood cholesterol. According to the American Heart Associa

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ion or AHA, a person’s total fat intake should be no more than 30% of his or her daily calories. The AHA also recommends that both your saturated and polyunsaturated fat intake

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

should each be limited to less than 10% of your daily calories. To help you stay on the safe side of things, here are some suggestions that you might find useful:

•Choose you

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

meat well. As much as possible, go for lean meat. Scour the grocery freezers and buy “Select” meat cuts that only contain a mere 15 to 20% fat. Stay away from “Prime” cuts w

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ich are about 40 to 45% fat by weight!

•Do not consume more fat than what is allowed in your diet. If you are on a 2,000-calorie diet, you are allowed to eat no more than 22 g

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ams of fat per day. This one is non-negotiable and there should be no ifs and buts about it. Go for low-fat versions of your favorite foods to satisfy your taste buds without

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

oing any further damage to your health!

•Not willing to give up your steaks? Well, there is a safe way to go around this matter! Just keep your portions small (3 ounces per s

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

rving or about the size of a deck of cards) and you can enjoy your steak the way you used to!

•Use fats that are liquid (or as close to the liquid state as possible) under room

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

temperature. So, if you are going to use margarine, choose those in tubs or squeeze bottles and not the more solid ones.

You can’t go wrong with carbohydrates. The AHA stress

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

s the importance of complex carbohydrates in your diet. These foods fill you up and can make you feel more satisfied. Thus, you may no longer crave for second servings or dess

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

rt. According to the dietary guidelines set by the AHA, your carbohydrate intake should make up for about 50% of your daily calorie intake. So, eat a lot of fruits, vegetables

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

whole grains and rice for a healthier you!

Eat fish - Fish contains a lot of omega-3 fatty acids, which can lower a person’s cholesterol levels. Now, don’t you think it’s hig

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

time for you to include lots of fish in your diet?

Cook your food wisely! Some of the more heart-friendly ways of cooking your food includes grilling, broiling and steaming.

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

Avoid fried foods as much as possible. They are no good for you!

Follow these guidelines and you can quickly be on your way to lowering your cholesterol - safely and healthily

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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