Advice Pool - Health and Fitness

Did you know that long steady cardio exercise, like running, has now been scientifically proven to be detrimental to your health? According to research by Dr. Al Sear

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

s all those long jogs can result in cardiac distress, a shrinking of the heart, a reduction in bone density (causing osteoporosis) and a general gain in fat once exer

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ise ceases.

First, let’s look at the distress that long steady distance running puts on your heart. Evolving from our hunter gatherer days we had no real necessity t

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

run long distances, in fact the only running we ever did was in short bursts to avoid predators or to catch food. Our body simply isn’t designed to run long distance

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

and the stress you put your heart under during this time can set you up for a heart attack. It’s a fact that many marathon runners do die of heart attacks.

Second,

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

his type of cardio reduces the size of our heart rather than strengthening and increasing its size. Our body is a fantastic machine capable of adapting to anything wi

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

h time; if we run long distances our body adapts to be more efficient at this activity. Fat is the preferred energy source from our body and so the more you train lon

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

g distance the more efficient the heart becomes at using less fat. To be more efficient the heart will shrink in size, just like the engine in a scooter is more effic

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ent than a 4x4.

Third, repetitive forces that are put through your joints like the ankles, knees, hips and back not only create repetitive injury but also reduce the

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

bone density. Strength training is the key to improving bone density, keep the exercises short and with plenty of resistance. This type of training forces the bones t

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

grow stronger, remember the body is a master adapter, so that next time you perform your strength exercises your bones are more capable of dealing with the strain. L

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ng steady cardio puts your bones under undue distress and causes them to prematurely break down.

Finally, losing fat is about becoming less efficient with your fat e

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ergy supply so you use up more and produce less. Long steady cardio does use more fat than any other type of training during the exercise itself. However, as the body

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

uses a lot of fat as energy it then turns all further calories into fat ready for the next long cardio session. This is fine when you are training regularly because y

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ou are burning the fat during exercise but as soon as you stop that extra fat is going to keep on being produced. Back to square one! So long cardio sessions are not

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ood for fat loss in the long term.

So what is the answer? You must start training your heart like any other muscle in your body and in a way that it was designed to

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

e used – short bouts of quick exercise with high exertion. This type of activity is exactly what we evolved to do, think back to our hunter gatherer days. As I said e

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

rlier, our body is a master adapter and hard short bouts of exercise will induce an increase in heart strength and size. Also, as our body no longer requires the exce

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

s body fat to fuel our runs it will be used as energy for long term body maintenance. Combine this type of quick activity with some strength training and you are well

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

on your way to better health and fitness.

For more information on how to perform this type of training you can contact me via my website or sign up for my newsletter

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Advice Pool - Long Cardio Is A Killer And Increases Your Body Fat

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