Advice Pool - Health and Fitness

Not long ago, one of my friends told me about guerrilla cardio as his favorite fat burning car

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

dio workout. Have you heard of it? It's an ultra-intense cardiovascular workout based on a stu

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

dy done by Dr. Izumi Tabata, Ph.D..

Dr. Tabata, a researcher at the institute of Health & Nut

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

rition in Tokyo, Japan, conducted a study compairing cardiovascular endurance training vs. hig

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

h intensity cardiovascular training. In Tabata's study, one group did a full 60 minutes of mod

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

erate-intensity exercise 5 days per week. Group two also trained 5 days a week, but performed

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

up to eight 20-second sprints of high-intensity cycling with a 10-second rest (pedaling at a s

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

lower rate) in between [1]. They performed these sprints between warm-up and cool-down periods

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

.

Tabata found that group 2 athletes on the high-intensity program, got fitter faster than gr

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

oup 1 athletes who focused on endurance training despite the large difference in time spent wo

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

king out (each day group 1 did 60 minutes & group 2 did 4 minutes). After this study was relea

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

sed, Muscle Media magazine published an article in October 2001 entitled: Guerrilla Cardio, wh

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ich suggested a cardio program based on these findings.

Guerrilla Cardio

Minutes 1-4:
W

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

arm-up 50% perceived exertion

Minutes 5-8:
Sprint- for 20 seconds
Rest- 10 seconds<

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

br> Repeat

Minutes 9-12:
Cool-down at 50% perceived exertion

Are you wondering how 4 m

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

inutes of exercise can burn more than 60 minutes?

Guerrilla cardio is an extremely challengin

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

g cardiovascular program that will burn fat & if you really go all out, you will be exhausted

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

at the end of this workout. This protocol does have some limitations when it comes to incorpor

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ating it into a fitness routine. If you would like to find out more, click here: elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

p://visfitness.blogspot.com/2007/05/guerrilla-cardio.html" target="_blank">Guerrilla Cardio

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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