Advice Pool - Health and Fitness

In certain cases asthma becomes very acute and many complications arise out of an asthmatic attack. Children and young adults are more vulnerable to sudden and unpredictable attacks of asthma. These attacks are mostly triggered by allergens and ex

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

cessive exercise. The immediate treatment for these is a puff or two of the inhaler or a nebulizer.

But if these conditions of persist for a longer duration it is in the best interest that a doctor should be consulted immediately. The patients wh

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

repeatedly show such tendencies of persistence of symptoms should never take their condition lightly. They should also be referred immediately to a hospital fully equipped with facilities to deal with any kind of emergency.

Also it is generally

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

een that a specialist in dealing with asthma cases is a much more preferred doctor in such cases. Most of the time it is seen that the people do take care to report emergencies when their kids are involved but they do not take enough care of thems

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

lves and do not report their own problems in time. This many-a-time aggravates their situation often making it go completely out of hand.

There are some signals that to an asthmatic person indicate hospitalization. The early warning signs that an

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

asthmatic person should never negate are:

· Fast heart rate and rapid respiration.

· Major problem in breathing by the use of neck and rib muscles.

· Severe case of wheezing.

· Persistent sweating.

· Cyanosis or blue colour in lips and finger

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

nails.

· Perplexed state of mind and reduced clarity in thinking.

The patients should be hospitalized and given oxygen inhalation therapy. Along with these several drug therapies are also given. Most of the patients recover after hospitalization

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

of five to seven days.

There are some cases in which asthma can turn life threatening. These patients experience a situation called acute respiratory failure. In this condition the bronchial tubes are completely blocked. The lungs in this conditi

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

n are devoid of life sustaining oxygen and they also cannot get rid of the toxic carbon dioxide. In such severe condition the machines called ventilators are used to take up the function of respiration.

The respiratory muscles are deliberately pa

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

alysed in this process and the ventilator takes up the control of respiration. This process is called assisted ventilation and it can safely be continued for two or three days. When the patient starts to improve, the machine is gradually turned do

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

n and the person is weaned away from the machine.

This process is available in bigger hospitals and has very low mortality rate. Along with a lot of anti-inflammatory drugs are given with intervention properties. This makes relapses rare and ther

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

e is very little scope of the asthma patient developing this condition again very soon. This is all thanks to the fast moving growth and constant changes that have happened in the field of medicine and health care. So many incidences prove beyond

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

oubt that if the patient gets medical attention in time he or she is sure to be saved and may even have chances of not having a repeat of same condition for a long time.

But many studies point towards a stark reality that most of the deaths from

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

sthma occur at home or on the way to the hospital. The lack of availability of medical attention at the time of death also does not prove anything or point towards any concrete conclusions during the last moments. In such an event it becomes almos

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

next to impossible to derive the exact reason why such episodes of fatality actually occur. Asthma researchers are now concentrating deeply on studying the patients who make it to the hospital and do emerge as survivors after a fatal asthma attac

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

. These near fatal asthma attacks are termed as “sudden asphyxic asthma”.

After several studies of patients with near fatal attack of asthma it was found that the patients who survived and those who did not had many things in common and some diff

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

rences too. On the basis of studying the two groups of patients one who survived and one who did not some very clear characteristics appear that help in developing the profile of patients who are at risk of developing near fatal asthma. These crit

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ria can be enlisted as:

· The patients show a history of seizures along with asthma.

· There may be done a recent change in drug treatment or administration dosages.

· There may be wheezing and other symptoms that may be neglected constantly.

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

Even at the time when the patient may be discharged from the hospital after treatment from near fatal attack he may be having some wheezing.

· There may be lack of self care at the hospital.

· There may be emotional conflicts between patient, h

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

spital staff and other family members.

· There may be a tendency in the patient to use their asthmatic condition as a tool for emotional manipulation of others.

· Severely dysfunctional family situations.

· Symptoms of mild to chronic depressio

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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