Advice Pool - Health and Fitness

Usually people ask themselves if maybe a bowl of oatmeal could prevent a heart attack or if your plain baked potato dressed in

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

sterol-fortified margarine could do the same thing as well. In order to stave off a cholesterol problem you could simply tweak

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

our diet.

Oat bran and oatmeal

LDL is the acronym for your low-density lipoprotein, also known as the bad cholesterol.

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

Oatmeal contains a soluble fiber which helps reduce this lipoprotein. Also, the same soluble fiber can be found in prunes, pear

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

, psyllium, apples, kidney beans and Brussels sprouts. This soluble fiber works in your intestines and helps by reducing the ab

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

orption of cholesterol.

For example, you can reduce your LDL cholesterol level with about 5 percent, by introducing five to te

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

n grams of soluble fiber a day. Eating about 2 cups of cooked oatmeal provides you with about 5 grams of fiber which is enough

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

o lower the cholesterol level. Oat bran or cold cereal made with oatmeal or oat bran can also be very helpful.

Walnuts

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

Recent studies have shown that blood cholesterol can be significantly reduced by walnuts. Besides this, walnuts help keep blood

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

vessels healthy and elastic as a result of the polyunsaturated fatty acids. Marked improvement is shown within just three or fo

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

r weeks with both almonds and walnuts.

LDL cholesterol can be reduced by 12 percent by keeping a cholesterol-lowering diet in

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

which 20 percent of the calories come from walnuts. A little less than 1/3 of a cup of walnuts is about 240 calories, which in

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

1200 calories per day diet means about 20 percent of the total.

Usually, just a handful of walnuts will suffice, because all

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

uts are high in calories. Avoid gaining weight as it is known that with any food (no matter good or bad) eating too much can le

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

d to such a reaction. Being overweight places you at a higher risk of heart disease. You can replace foods high in saturated fa

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

with nuts in order to avoid gaining weight. Add a handful of nuts or almonds in your salad instead of adding any luncheon meat

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

, croutons or cheese.

Soy

Recent studies from the AHANC (American Heart Association’s Nutrition Committee) have shown

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

hat soy protein does not have that great impact when it comes to reducing cholesterol levels, even though it has been believed

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

or a long time that it would have a great lowering effect. Actually, the American Heart Association stated that the soy protein

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

has no influence on HDL, triglycerides or blood pressure, not even in large quantities. It only has shown a small impact on LDL

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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