Advice Pool - Health and Fitness

There is no question that depression necessitates treatment in some form. Many people benefit from some combination of the various therapies especially thos

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

e who require long term treatment. There are a number of treatments of depression and they include Pharmaceutical/ Prescription medications, Psychotherapy (

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

alk therapy), Exercise, Electro-convulsive Therapies, and Vagal Nerve Stimulation.

Pharmaceuticals or prescription therapies include three classes of antid

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

pressant medications: MAOIs-Monomine Oxidase Inhibitors, TCAs-Tricylics, and SSRIs-Selective Serotonin Uptake Inhibitors believed to release chemicals in th

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

brain that improves signal transmission between nerves.

There are two other pharmaceutical therapies available. One is Booster Drugs. These work in conjun

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

tion with the primary antidepressant that may be prescribed. Booster drugs work well about half of the time. The most popular booster drugs include Ritalin,

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Lithium, and Cytonel.

The next pharmaceutical treatment protocol is Hormone treatments, a therapy typically provide for women in all phases of menopause. T

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

e thinking is that women become depressed because they have an imbalance of Estrogen and Progesterone that can be verified. The dosage is different for each

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

individual based on the level of deficiency that is found. In order to get this treatment you must be evaluated by a skilled neuro-endocrinologist. This is

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

relatively new treatment but it is showing a lot of potential.

Psychotherapy is also known as talk therapy. There are a number of types of or components o

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

psychotherapy including cognitive- behavioral in which the thinking and actions of a person are assessed and overcoming issues are taught. The Interperson

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

l approach evaluates how one individual relates to others (family, coworkers, and friends). Psychodynamics evaluates the emotional and motivational forces t

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

at may affect behavior and the mental state of an individual.

Exercise can be any form of physical exercise including aerobics, yoga, and others. Exercise

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

s believed to release chemicals in the brain that affect both mood and pleasure. It also has the potential to make the body more fit and toned.

Electro-con

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ulsive therapy-ECT is also known as shock treatment. In this treatment an electric shock (or shocks) is delivered to the body to induce seizure activity. Wh

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

le there is some efficacy with this treatment, this therapy could cause memory loss, severe headaches, and possibly more seizure activity with future treatm

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

nts. It is usually prescribed once a month or every 3 months or so.

Vagal Nerve Stimulation (VNS) is a small pacemaker type device that is inserted in the

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

hest. Electric pulses are delivered along the Vagal nerve that runs from the neck to the brain thought to control depression.

All of this information must

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

eem somewhat overwhelming. Consulting with your doctor as to the best course of action for you is of paramount importance. Suffering with depression is over

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

helming in itself and looking at all the treatment options even more so. Don't reject treatment if you can help it. Treatment can make things so much better

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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