Advice Pool - Health and Fitness

Human being is the god’s best creation. Every body has some problem in their lives. Some has financial problems, some are facing family problems an

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

d some the most critical problem i.e. health problem. Constipation, indigestion, jaundice, skin problems, liver disease are few problems that human

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

being face very frequently.

Now a day, herbal medication is on the top. Herbal plants are used for the herbal medication. Herbal plants either gro

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

naturally or are cultivated. Besides being used in pharmacies and cosmetics, it is also used as spices or flavoring agent. SENNA is one of the her

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

al plants which used to treat above problems. Senna is the member of Leguminaceae family. Actually senna is the shrub which is mostly found in chin

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

a, Pakistan and India. Senna is also used as a stool softener. Senna is used to treat the bowel. Senna leafs in the paste form can be applied to ma

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

y skin related problems.

Senna pods and senna leafs are used for the medication. Senna leafs are WHO (world health organization) approved. Senna l

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

afs are commonly used for constipation treatment. You can also use it to treat ringworms, acne and other skin diseases. Senna leafs get matured fro

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

the seed. Its height is around 5 to 8m. It grows like a straight woody stem with bunch of flowers. These bunch of flowers turns into the senna po

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ds. Senna pods are used as a laxative for centuries. Cassia angustifolia is the scientific name for senna pods. Overdose of senna pods can lead to

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

a diarrhea or stomach cramps.

Before taking senna dose let your doctor know whether
• You are pregnant.
• You are breast feeding.
•

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

You are taking some other pills.
• You are having other health problem.

Dosage:
Don’t start taking senna without any consultant. Ask you

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

care taker for the dosage. Dosage depends on the reason why you are taking and how powerful the medicine is.

Where to store:

Keep the medici

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ne in cool and dark place. Avoid it from the direct sunrays. Keep it away from the reach of children. Throwaway the out dated medicine and never tr

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

to share your medicines.

Warnings:
• Consult your doctor before use of senna.
• Don’t use senna for more than 1 week.
• Don’t use

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

f you are below 12 years.
• Don’t use if you are breast feeding or pregnant.
• Don’t use senna if you are having a problem of appendiciti

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

.
• Don’t use senna if you had a stomach pain.
• Use of senna for long time and in excess amount can make your body prone to it.

Side ef

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

fects of senna:
• Chest pain
• Skin related problems like itching or swollen skin.
• Breathing problem or tightening of chest or th

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

oat.
• Stomach cramps or pain or diarrhea.
• Reddishness around anus or itching.
• Change in the finger nail.
• Change in the c

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

lor of urine like pink or yellow-brown.
If you feel any of the above symptoms then immediately stop the intake of medicine and ask your doctor

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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