Advice Pool - Health and Fitness

It is quite easy to find fruits in open market. We know the fruits come chemical treated at various stages. Most fruits we consume are

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

grown and preserved with chemical aid.

Think how a fruit is grown in a farmer’s orchard. The plant is supported by chemical fertilizer

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

. These fertilizers help the plants grow fast and yield more fruits. Abundance of pesticides and insecticides are applied at the orchar

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ds to prevent pests and insects. In many cases of mechanized harvesting, chemicals are also applied for quick falling of unripe fruits.

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

It goes without saying these chemicals ultimately accumulate in human bodies, causing several health problems at a later period.

Natu

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

rally occurring fruits are hard to come across and usually involves efforts from your own part to take a trekking to the wilderness. If

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

you are at the local markets near hill stations of Kerala, your luck rate is higher to find naturally bred fruits grown in thick dense

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

forests. Not only Kerala South India, but tropical countries of Africa are also rich source of natural fruits that are not contaminated

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

by chemicals.

Wild plants generally produce lesser number of fruits and the size will also be smaller. Such fruits however have the ad

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

vantages that they are never fumigated or otherwise chemically treated for bigger size, better taste or large quantity produce.

The gr

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

pes you buy from general market have pesticides on its skin. This pesticide is not quickly rinsed away. The result will be more chemica

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ls in your body.

There are also scalable differences in the performance of naturally grown fruits and chemically treated artificial fr

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

its.

While natural fruits stay fresh for a few days after falling down or harvesting, chemically treated fruits rot in a day or two. T

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

his is the same for all kinds of fruits.

Natural fruits tend to bear highly functional seeds. Most artificially cultivated fruits have

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

seedless varieties or varieties with poorly developed seeds. The artificial fruits generally are in the ‘sterile’ zone. I.e. they are n

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ot capable of reproduction. All of the examples suggest that cultivated and chemical treated fruits are inferior to naturally occurring

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

fruits.

It is not practicable for everyone to find naturally occurring fruits from the forests. The closest healthy alternative to goi

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ng to forests is growing organic crop. Though the plants doesn’t get a wild environment where there is the right supply of temperature,

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

water, bio-nutrients etc; chemical treating is absent.

No GM crops apply here. Organic food is fresh and doesn’t inject harmful chemic

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

als to your body.

Vegans claiming to eat only healthy food do have a challenge before them to ensure if they are eating healthy fruits

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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