Advice Pool - Health and Fitness

Arthritis is one of the biggest problem that has been faced by million of people worldwide. Arthritis is a general term that literally means pain and inflammation in joints. Though previously it was believed that only old peop

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

le suffers from arthritis but now it has been seen that people of younger age group are also being affected by this disease. Arthritis is not a disease in itself. There is a general condition in which the joint becomes inflame

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

d and causes great pain. Arthritis can be of many types but commonly three types are frequently seen. These are: -

(a) Rheumatoid arthritis
(b) Osteoarthritis
(c) Gout

(a) Rheumatoid arthritis – it is a kind of a

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

rthritis that is more associated autoimmune disorder that occurs due to attack of our immune system on the joints. It is also associated with the deformity in the body. It is commonly seen in people who are in their mid fortie

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

.

(b) Osteoarthritis – it is another form of arthritis that occurs due to age related changes. In this condition there is formation of osteophytes in the joints. The cartilaginous structure gets ossified and gets converted in

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

the bone. This bone formation in the bone leads to the hindered movements and causes extremes pain whenever the joint is made to move.

(c) Gout – it is concerned with the formation of uric acid crystals in the joint. Due to

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

any kind of deformity there is decreased in the serum uric acid metabolism thereby leads to the accumulation of uric acid in the joints. It is commonly called as the riches disease as it is more commonly seen in people who are

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

well off.

Causes

· Ageing
· Over use of joints
· Hereditary factors
· Wrong feeding habits
· Infections
· Metabolic disorder

Symptoms

· Pain in joints
· Swellings in joints

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

· Restricted movements
· Redness over joint
· Deformity of the joint
· Cracking sound on movements.

Treatment

Though the anatomical changes are very difficult to be reversed but their have been certain

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ayurvedic preparations that are extremely helpful in suppressing pain and prevent any further damage to the joint. Belo are few ayurvedic herbs that are very effective in curbing arthritis.

· Ashwagandha (withinia somnifera)

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

it is one of the best herb that has the potential to suppress pain and inflammation. It has certain properties that are very helpful in reducing the vata dosha in the body that is solely responsible for causing all pains and

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

inflammation in the body. Ashwagandha is a medium sized plant that is easily found in areas having warmer climatic conditions. The roots of Ashwagandha are the plant parts that are being used to make medicines. Generally Ashwa

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

gandha is taken in as powder form but it is now available in capsules and syrup forms also.

· Guggul (commiphora mukul) – Guggul is one of the most prestigious herbs that has been very popular among ayurvedic physicians. Gugg

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ul is vata suppressant and hence is widely used to treat vata related disorders. Guggul not only reduces pain in the body but is also responsible in suppressing any kind of inflammation and edema that occurs in the body. Vario

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

s preparations like mahayogaraja Guggul, laxadi Guggul, rasnadi Guggul and gokshuradi Guggul that are being widely used to curb any kind of pain in the body.

· Rasna (pluchea lanceolata) – Rasna is an excellent analgesic and

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

has excellent results in suppressing pain in the body. It is a small plant that can be used in preparing various forms of preparations. It is used as powder, decoction and oils. It has the potential to reduce the vata dosha in

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

the body and is very successful in curbing its effect.

· Arthcare oil – arthcare oil is one of the prestigious ayurvedic preparations that have been found extremely helpful in treating various pain disorders like arthritis,

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

usculoskeletal disorders, backache, joint pains, wounds etc. It has been empowered with the wonders of certain ayurvedic herbs like errand (ricinus communis), Rasna (pluchea lanceolata), devdaru (cedrus deodara), shuddha Guggu

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

l (commiphora mukul), rasone (garlic), marich (black pepper), nirgundi (vitex negundo), ajwain (trachyspermum) and til tail (seasum). These all herbs are famous for their activities in suppressing and curbing any kind of pain

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

and inflammation that might occur in the body. The oil is gently massaged on the affected part and then hot fomentation is done. This is the simple procedure that is all you have to do to get relief from the pain and arthritis

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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