Advice Pool - Health and Fitness

Stem cell technology and anti-aging skin care is a new phenomenon sweeping the cosmetics industry. In 2005, rumors began to surface about a stem cell bas

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ed mystery skin cream that was not only the most controversial, but also the most sought after anti-aging cream in the world. Consumers were seeking Amat

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

okin, a product which is now more readily available as a result of its recent and exclusive launch at Bloomingdales.

Amatokin is said to be the most prof

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

und skin care advancement in more than three decades. According to its manufacturer, Voss Laboratories, the emulsion is the first product to harness the

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

regenerative potential of your own facial stem cells to renew the skin and make it look young again.

The marriage of stem cell technology and anti-aging

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

skin care is highly controversial. Some researchers believe that the use of stem cell technology for a topical, anti-aging cosmetic trivializes other, mo

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e important medical research in this field. Secondly, confusion exists over the type of stem cells being exploited in this particular cosmetic product.

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

Stem cells have the remarkable potential to develop into many different cell types in the body. When a stem cell divides, it can remain a stem cell or be

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

come another type of cell with a more specialized function, such as a skin cell. There are two types of stem cells, embryonic and adult.

Embryonic stem

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ells are exogenous in that they are harvested from outside sources, namely, fertilized human eggs. Once harvested, these stem cells are grown in cell cul

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

tures and manipulated to generate specific cell types so they can be used to treat injury or disease.

Unlike embryonic stem cells, adult or somatic stem

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

cells are endogenous. They are present within our bodies and serve to maintain and repair the tissues in which they are found. Adult stem cells are foun

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

in many organs and tissues, including the skin. In fact, human skin is the largest repository of adult stem cells in the body. Skin stem cells reside i

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

n the basal layer of the epidermis where they remain dormant until they are activated by tissue injury or disease.

Amatokin is the first product of its k

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ind and works by stimulating the adult stem cell reservoirs in our skin to help rejuvenate it. From the day we are born, our skin experiences the increme

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

tal and cumulative effects of intrinsic and extrinsic aging. When we are young, stem cell utilization for skin rejuvenation functions efficiently. As we

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

age, it reduces significantly. Given the proper environment, these inherent stem cell reservoirs can be stimulated to renew the skin.

Amatokin is an an

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ti-aging skin care product that addresses the expression of stem cell markers in the skin to reportedly reduce the appearance of serious wrinkles without

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

njections or even a visit to the doctor’s office. Could it truly be a “miracle in a bottle”? As with any new and innovative technological advancement in

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

anti-aging skin care, time will tell. I’m sure this is only one of many products to come that will combine stem cell technology and anti-aging skin care

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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