Advice Pool - Health and Fitness

Your posture is your attitude to life. Everyone has one, and like a skeleton in a closet, no one wants to talk about it. And yet it is one of the most important aspects of life. It defines who we are, both to ourselves and to how other

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

s see us. It also ultimately defines a great deal of our health.

You may have the most brilliant personality, the most brilliant mind, or be the funniest person in the world, but when you meet new acquaintances, their first impression

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

is, alas, visual. Do they see you as hangdog, defeated, a loser? Or a vital person, a person to trust, to look up to, one to be admired and listened to.

But my posture is good! Well is it? Let’s check it out. The quickest (not the mos

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

t analytical), is to simply strip down to your underwear, swimsuit etc. Now stand side on to a full length mirror. Stare ahead for a full count of 60 seconds. Glance at the mirror without changing your body posture. See yourself.

Alter

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

natively, and easy enough to do in this day of the digital camera, a more objective study is to take a picture in this posture. This time count to 120 seconds, have your buddy take a side-on picture. Print out this image. Take a ruler a

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

nd place it on the photo from the middle of the ear (external auditory meatus) to the knobby bit on the outside of the ankle (lateral malleolus). Good posture would also have this line passing through the tip of the shoulder (acromiocla

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

vicular joint), the outermost bony point of the hip (greater trochanter) and the outside bony point of the knee (lateral epicondyle).

Still think you still have good posture?
What can you do to improve the situation?

But fir

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

st consider, from your personal posture, how forward is your head from a perpendicular line drawn straight up from the shoulder tip? Research has shown that if the head weighs 10 pounds and if the head is forward one inch from our shoul

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

der tip line, it will effectively weigh 20 pounds, 3 inches would be 30 pounds. Scary isn’t it? Now you will not be able to calculate that from the photograph. But a visual will give you an idea of the stresses being transmitted to your

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

neck and upper back.

Unfortunately, research has also shown that when loads are altered from the normal, bone accommodates correspondingly. In this example, with the forward head, the neck will likely lose its normal forward curve (lo

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

rdosis) and develop a reverse curve (hypolordosis) resulting over time in bone spur formation (osteophytes). This is a natural reaction to physical stress of this nature. Posture. Makes you wonder why we don’t talk about it more.

So h

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ow did we get here? Part of the answer is laziness, part of the answer is our posture in everyday activities. How do you sit when working at the computer? Or when watching TV? In addition, when we hurt ourselves, pain and discomfort ar

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e the natural consequences. Our body then adapts to restrict certain movements, the ones that increase the pain. We learn to avoid certain movements which then increase joint stress and strain. This then becomes a habit which unfortunat

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ely causes unequal muscle and ligament balance. Habits, good or bad, are what we do. Practice doesn’t always make perfect, but it does make for permanent.

Habits shape our bodies, our posture. We learn to do whatever we do repeatedly.

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

If you sleep on your stomach, face turned to the left, when standing you will notice your head doesn’t turn as easily to the right. At work you prop that phone under your chin and hold the ear to the shoulder all day long. Your head wil

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

l want to go that way when you are not at work. Both these conditions will now worsen as you get older.

These are just two examples. Work out what your habits (unbalanced ones) are. Then try your best to change them. Think of balance.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

One side to the other. This is a good start, just realizing you need some self help. Further, work on these easy and simple exercises. Sitting, relax shoulders, pull your chin back, not looking up, down or sideways. Pull back till you

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

feel a slight pull to the muscles in the back of the neck, just below the skull. Hold for a slow count of five. Repeat 20 times, two times per day at least.

Still sitting, hands resting on knees, keeping the shoulders straight and even

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

, move your shoulders back squeezing the shoulder blades together. Hold for a count of five. Repeat 20 times, two times per day at least.

An even easier movement is the abdominal pull in. Breathe in then breathe out slowly to a count o

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

f five, pulling the tummy in. Repeat 20 times at least twice per day. You should now progress to a series of stretching exercises that will further and more permanently rebalance and strengthen the muscles and ligaments of poor posture

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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