Advice Pool - Health and Fitness

Sadness is normally due to, or the cause of, dwelling on what made us sad and downhearted in the first place. And with feelings of depression, the

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

only remedy is – to remove – or remove oneself from the cause!

As for sadness, it is easy to say “stop thinking about it”, because it is deep i

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

n our psyche to – for instance, from a friend or love one to feel cheated or betrayed or from someone “least expected” to feel hurt, left alone, a

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

nd cheated where ones trust was misplaced. But it helps to understand the painful truth, that “all suffering is self - inflicted”! Yes! Also in ca

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

es like these! Its soon goes away and “justice” is done with the realisation of the truth: By telling ourselves that – the loss of a friend or a l

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

oved one (if by death – he is no longer suffering! And the pain we feel through this loss is only OURS – our hurt! What is wrong with paying respe

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ct to his or her demise with an awareness of this condition and carrying their memory and our loss with quiet dignity?

When cheated or betrayed o

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

let down by someone, why not tell oneself that the “cheater” is not worthy of so much pain and therefore has no longer deserved another thought.

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

When you feel let down, admit to yourself that it may not have been all his fault, but more so your own by “expecting too much of him”! Aching hea

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

rts soon heal when one sees things in a “less self centered light”. It hurts to be hurt! But what for! If it was not your fault in the first place

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

If it was, however, and you suffered sadness due to a deed or action you have caused and now regret, because it was undeserved and you now feel

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

truly guilty about, suffer if you must! But tell yourself that everyone makes mistakes, misjudges, has reasons of moments of anger or “getting eve

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

n”!

You can make it up to him or her! Quite often an apology or a little token of thoughtfulness (a small gift) works wonders. The gesture and th

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

e acceptance of it makes your sadness or suffering go away!

If loneliness gives you a feeling of being deserted and causes you to be sad – go and

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

visit a friend! Ring one up and plan an outing for a luncheon or shopping spree together, and your spirits will already be lifted through “somethi

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ng to look forward to”! Why not go for a drive to a nice quiet spot, where you will be alone, but close to nature! T.his also works wonders!

Don’

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

t be sad or depressed! It does not pay! Either for yourself or another person concerned! Paying tribute to a lost friend or loved one with respect

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

and dignity will suffice! And the other reasons – ask yourself honestly whether you in some way have not “asked” for it and are completely guilt -

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

free in the “let down”! Do what you can to “make up” or “put right” of what was your fault in the matter! Otherwise put it out of your mind, forg

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

et what goes with it, and start something new, something better, and - if you can – something else! It works wonders with forgetting and forgiving

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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