Advice Pool - Health and Fitness

The numbers are staggering. The National Institutes of Health estimates that 9.5% of us will experience some form of depression during any given calendar year and the World Health Orga

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

nization found that depression is so common that by the year 2020, depression will be the second leading cause of disability worldwide.

Unfortunately, natural and alternative medicine

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

as little to offer someone who is severely depressed but if you deal with infrequent bouts of mild depression ask your doctor if adding behavioral modification, dietary changes o

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

r herbal supplements is appropriate for you.

Behavioral modifications like learning to recognize and arrest negative self-talk can be an effective way to stem mild depression b

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

fore it gets a chance to progress. Your doctor can refer you to an appropriate therapy program that will help you understand exactly what self-talk is and how it can be used to combat

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

depression naturally.

Dr. Andrew Weil calls exercise "the most effective treatment" he knows for mild depression. Running a marathon may be the last thing you want to do when you'

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e depressed but a light daily exercise program (like walking for 20 minutes a day) may be very helpful in the battle against mild depression.

Sunlight exposure--or a lack of it--se

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ems to play a significant role in some people's vulnerability to depression, especially the type of depression doctors call seasonal affective disorder or SAD.

Caffeine and alcohol

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

avoidance may be helpful for some people struggling with depression. Both of these substances play a significant role in mood and can make mood swings more pronounced.

Omega 3 fat

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ty acids are a relatively new tool in the fight against depression. Omega 3 fatty acids seem to play a vital role in the fight against some forms of depression. Scientific research is

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

sketchy at this time but we know that the Japanese, who eat more than 3 times the amount of omega 3-rich fish (like salmon) than we do, have the lowest rates of major depression in the

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

industrialized world.

5-HTP is a substance made in the brain from the naturally occurring amino acid trytophan. For decades, nutritionists have recognized tryptophan's role in ser

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

tonin production but tryptophan has also been linked to liver damage and asthma attacks so it's no longer recommended routinely. 5-HTP should never be taken by pregnant women.

St.

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

Johns Wort, known botanically as Hypericum perforatum, has been shown to be as effective as prescription anti-depressants in over 30 double-blind studies. Unfortunately, it hasn't sho

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

n much promise to the severely depressed, but for bouts of mild depression, it seems to an effective option for some people. St. Johns wort is known to react with several prescription

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

drugs so never begin a regimen of St. Johns wort for mild depression without first discussing it with your doctor.

SAM-e is perhaps the most promising of the natural treatments for

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

mild depression. SAM-e, or s-adenosylmethionine, is a compound made from methionine, an essential fatty acid needed naturally by our bodies. SAM-e works by increasing the activity of

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

neurotransmitters like dopamine and serotonin. SAM-e works faster than St. Johns wort and 5-HTP and doesn't seem to have any serious or long-term side effects.

As with any medica

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

condition, it's extremely important that you work with your doctor to develop a whole-life approach to your depression. Suddenly stopping your prescription medications can be dangerou

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

s so always consult your doctor first. And let him know about any herbal or nutritional supplements, too, to prevent potentially dangerous interactions. You can beat depression

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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