Advice Pool - Health and Fitness

Bitter melon or bitter Gourd is a popular vegetable throughout the world. It is especially popular in South East Asia where it goes by a variety of names and is used

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

as a medicine and in cooking. It's botanical name is Mormordica Charantia. Mormodica is Latin for bitter and Charantia is Greek for beautiful flower. The fruit of the

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

bitter melon looks like a large zucchini but has a light green skin that is distinctively rough and bumpy. It is claimed to be good for managing diabetes. This articl

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

e will examine the claims and look at how people use the vegetable.

It is claimed that bitter melon has hypoglycemic effects on the body. In other words, it reduces

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

he level of glucose in the blood. There have been numerous studies done in laboratory conditions and on mice and human subjects. The vegetable is particularly popular

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

in the Philippines where a number of studies have taken place. One such study was carried out by at the St. Luke's Hospital, Quezon City. Two test groups were given a

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

tea to be consumed after a meal over a period of 24 weeks. One tea had a bitter melon supplement added while the other was a regular tea. Over the period of the test

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

it was noted that the people drinking the bitter melon tea had a lowered blood sugar level by comparison to the normal tea drinkers.

Other experiments have confirmed

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

this finding that bitter melon can be used to control blood sugar levels. However research into the vegetable is still needed to determine why it has this affect on b

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

lood.

There are few theories as to how bitter melon works.

The first is that it helps the beta cells in the pancreas to recover. Beta cells are responsible for prod

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

cing insulin in the body. Insulin is the body's way of reducing blood sugar levels by metabolizing the sugar as energy. In type 1 diabetes it is thought that the beta

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

cells are destroyed by the body.

The second theory is that the vegetable helps the liver to use or store glucose. Excess glucose in the blood is converted to glycoge

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

n in the body in the muscle, fat and liver cells thus reducing the blood sugar level. In diabetics this does not happen.

The third theory is closely related to the f

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

rst, in that the vegetable or active ingredient in the vegetable activates insulin secretion. This could be seen as more useful to people with type 2 diabetes because

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

they are essentially insulin resistant. Although we do not know why the body becomes insulin resistant it could be that the insulin is not secreted at the proper time

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

.

Bitter melon is taken in a number of ways. It can be taken as a dried extract in teas or other beverages that help it to dissolve. The fruit can be liquidized with

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

a favorite juice and taken as a refreshing cold drink. The vegetable can be used in many types of food. It can be cooked from raw in a Asian style stir fry meal or in

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

an Indian curry.

Bitter melon is sometimes known as vegetable insulin because it has the same or similar effects as animal insulin on the body. You should, however,

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

consult your doctor if you plan to start using bitter melon. You shouldn't stop taking any prescribed medication either. Consult your doctor if you are pregnant and w

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

nt to start taking bitter melon. It is best to trial it along side your current diabetic treatment and analyze the results before making any changes to your treatment

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Advice Pool - Bitter Melon - A Natural Remedy For Diabetes?

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