Advice Pool - Health and Fitness

In recent years, a lot of interest has been directed at the use of silver in footwear. Silver has long been used as an antibacterial agent going back to ancient

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

times. Today, it is used to cure burns and stop infection.

So, how does it affect the foot? Think about your shoes for a moment. Pick them up. Hold them to your

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

face. Take in a deep breath…

Hesitant?
Why?
Do they smell?

That smell is a primordial soup of bacteria, ammonia, and denatured proteins (i.e. dead sk

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

in, etc…). It is known as an odor triangle. Bacteria takes up residence in your shoes. It eats the proteins and when it dies, the by-product is ammonia. T

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

hat’s what has been growing and dying within in the warm, moist confines of your shoes. That is what stinks and what is worse, it is touching your feet!

But ther

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

is a savior. It is silver. What silver does is strangles bacteria. Silver stops the respiration and reproduction of bacteria which kills it, stopping odor from o

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ccurring. Once the bacteria is gone, the smell goes away.

That’s a relief. So silver can get rid the stink out of your nasty shoes. But how is this helpful to an

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

yone but your spouse? Well, what if you were diabetic? We’ve all heard the horror stories of how people with diabetes can lose their toes and feet. Well, that h

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

appens because wounds occur and cannot heal because white blood cells are stopped due to poor circulation. Bacteria, found on the socks and shoes, enters the woun

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

d and then infection sets in. Now, if you had silver in your shoes, this would go to work killing off the bacteria and would prevent most of it from entering the

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ound. It isn’t fool proof, but it is a great defense against diabetic foot problems.

Silver comes with an added benefit for you, too. It helps prevent blisters

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

and hot spots from forming. A blister or hot spot forms when there is a constant rubbing going on in the shoe. This can be because the shoes don’t fit properly or

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

you are doing something repetitive – like walking or running! Well, just like rubbing two sticks together to make fire, rubbing your foot against the inside of y

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

our shoe will cause friction which will lead to a blister. Silver has a way of transferring heat. So, if it becomes hot at one point, the entire area takes on a l

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ittle part of that heat and spreads it throughout the surface of the material. Basically, this means you won’t get blisters, because the heat isn’t concentrated o

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

one area. Your foot stays cool and you don’t get the pain.

You can find all types of silver clothing all over the internet. Silver shoes are a bit harder to fi

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

nd. I know of only a couple of places that provide this type of footwear. You can find the shoes at www.footwearnmore.com. Here they have orthotics and socks wit

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

h silver in them, as well. The site also has a variety of other products for people with diabetes or people that are just looking for comfortable shoes. Silver h

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

as a lot of benefits and is very much a secret in the footwear or diabetic industry. In the past three years, articles are just starting to emerge showing its’ b

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

enefits for people with diabetes. The sports industry has been using silver in its’ clothing for quite awhile and will soon be a known product in medical footwear

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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If you’ve been looking for a job for any length of time, you’ll notice there are many out there beyond your level of expertise. Why is that? Is it because of your education? Your lack of experience? If you want to move ahead in your career, sometimes you need to make yourself more marketable. How exactly can you do that?

Most of the people searching the internet are doing it via the major search engines and directories. So how can you get your share of that enormous amount of targeted traffic?

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