Advice Pool - Health and Fitness

Childhood obesity has become a worldwide epidemic over the past two decades. Between the availability of convenience and fast foods and the trend for children to be less active, obesity in childre

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

n has risen nearly 50%. It is estimated that 25% of children today are obese. Along with the childhood weight problems associated with obesity in children, many other health issues can occur such

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

as high blood pressure, high cholesterol levels, orthopaedic problems, sleeping disorders and the most prominent disease, type 2 diabetes.

The increase in type 2 diabetes in children has parall

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

eled that of obesity at an alarming rate. Less than ten years ago it was nearly unheard of for children to develop this form of diabetes. Type 2 diabetes was usually diagnosed in adults over age

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

0. Today, children as young as age 10 are being diagnosed with this dangerous disease. Left untreated, type 2 diabetes in children can progress into adulthood to cause blindness, kidney failure an

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

d heart disease.

What is Type 2 Diabetes?

Childhood Type 2 diabetes occurs when the body doesn't produce enough insulin and cannot use insulin properly, becoming

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

'insulin resistant'. When this happens, blood sugar levels skyrocket. Unlike type 1 diabetes, which you are born with, type 2 is attributed to lack of a healthy diet and exercise. Obese children

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

are at a greater risk of developing this disease compared to their more active counterparts.

Early Warning Signs of Type 2 Diabetes

Below are signs that w

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ill tell you if your child is at risk of developing type 2 diabetes.

Cholesterol - Have your child's cholesterol tested. Make sure to get the LDL (good cholesterol) and HDL (bad chole

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

sterol) tested separately. Signs of type 2 are shown in either too low LDL or too high HDL and triglycerides.

BMI and Growth charts - If your child is extremely overweight according to

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

he charts, or has had a large jump in weight, this is a warning sign Symptoms of Childhood Obesity and Type 2 Diabetes

Symptoms to watch for if you think

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

your child is at risk for type 2 diabetes.

High blood sugar levels - normal is in the 70 - 120 level.

Constantly thirsty, drinking fluids continuously.

Urinating mo

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

re often than normal.

Feeling weak and tired.

Darkening of the skin at the base of the neck, folds of arms or around the eyes.

Slow healing of cuts, bug bites, etc.

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

li> Prevention of Childhood Obesity and Type 2 Diabetes

Preventing the risk of developing childhood type 2 diabetes is as simple as eating a healthy diet and

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

xercising to prevent childhood obesity. You can start at any age, but the younger, the better. Some suggestions are:

1. Plan nutritious meals for the entire family choosing whole grain foods and

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

good fats along with plenty of vegetables.

2. Toss out the '3 meals a day' routine and serve children smaller, more frequent meals.

3. Choose healthy snacks for children like fruit or dr

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

y popcorn.

4. Limit television and computer games and encourage your child to do physical activities. Join in with them and enjoy the exercise.
5. Add activity in small ways, such as tak

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ng the stairs instead of the elevator, parking farther away from stores and walking or riding your bike instead of driving.

Changing habits developed since childhood may be difficult, but don't

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

discourage. The key to childhood obesity prevention is to make simple changes a little at a time until they become habit for you and your children. Remember, the changes you are making may save y

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

our child from a lifetime of illness.

For more information, parenting articles, free online weight assessment tools and downloads, childhood obesity advice, and other tips visit www.abcfitkids.co

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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