Advice Pool - Health and Fitness

In diabetes, the symptoms can vary depending on whether a person has type one or type two diabetes.

Before diagnosis the

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

symptoms may be more obvious, but after treatment and the glucose levels are more stabilized, diabetic symptoms will often

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

reduce or go away.

However, type 2 diabetes can be sometimes so subtle that there are no noticeable symptoms, and hence

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

s only diagnosed with a blood test.

In this article, let's look at the symptoms can be present in diabetes, both type 1 (

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

insulin dependent) and type 2 (non insulin dependent) diabetes.

The symptoms on type 1 diabetes

In type

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

1 or insulin dependent diabetes, the symptoms are serious and very severe when the illness starts.

The symptoms include

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

he following:

1. Excessive thirst and excessive drinking

2. Excessive urination, otherwise known as polyuria

3. Loss of

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

weight

4. Excessive hunger and eating. Notice how it's a condition where despite eating more, there's weight loss.

5. F

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

eeling unwell, getting infections

6. And type 1 diabetes can present as diabetic ketoacidosis. In this state, the sugar l

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

vels are very high, there's acidosis in the blood, and even collapse and coma.

So when type 1 diabetes starts, it's a ver

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

y serious condition that requires medical attention right away. Treatment is needed in type 1 diabetes and can't be revers

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ed with 'lifestyle changes'.

The symptoms on type 2 diabetes

The symptoms in type 2 diabetes include th

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

following:

1. Increased thirst and drinking

2. Increased urination

3. Recurrent infections such as skin infections eg

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

fungal or bacterial amongst others

4. Long term complications of diabetes.

Long term consequences of diabetes include he

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

art conditions, deteriorating eye health, kidney disease, peripheral vascular disease (blockages to arteries in eg the leg

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

causing pain in the legs during walking), and peripheral nerve disease.

Many people at risk of type 2 diabetes are also

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

overweight and have other associated conditions such as hypertension and hyperlipidemia.

So as you can see, there are var

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ious ways in which diabetes can present. In type 1 especially, the symptoms are serious and can be life threatening. It's

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

mportant to seek medical care immediately.

In type 2 diabetes, it can present with similar symptoms or sometimes more sub

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

tle symptoms.

In both cases, it's important to seek the advice of your doctor about how to manage and treat the condition

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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