Advice Pool - Health and Fitness

This week the British Medical Journal published a meta-analysis of the best approaches to treating type II diabetes. What the heck is a

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

meta-analysis? It is where a research group looks at all the previous studies they can find on a particular subject and puts them all to

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

gether to see how much the studies agree. This particular meta-analysis looked at all the ways to treat type II diabetes, whether it wer

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

e drugs, herbs, diets, exercise or combinations.

Diet, Exercise better than Drugs.

The researchers found that lifestyle approaches (di

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

et and exercise) were at least as effective as drugs in treating type II diabetes. This is an incredible finding because it provides sci

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

entific evidence for what many of us interested in natural approaches have already suspected. Furthermore, the report concluded that lif

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

estyle approaches had far fewer side-effects than drug therapies. This finding is not too striking but good to see the science nonethele

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ss.

So why are drugs so heavily used in treating type II diabetes when they appear to be unnecessary in so many cases? There are a coup

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

le of main reasons. First, people want a quick fix. Drugs provide that. Second, people don't want to work that hard to get better. Drugs

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

, also provide that. They are easy and relatively fast.

But the flip-side of the coin is, why would you willingly take a drug for the r

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

est of your life and suffer the side-effects when you don't have to? It all goes back to basic psychology. People do things to get pleas

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ure and avoid pain. In many cases, the pain of lifestyle adjustment outweighs the pain of drug side effects and the pleasure of not need

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ing drugs.

Change is the only Option

The irony is that anyone who actually makes the necessary adjustments, starts to exercise and eat

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

better, actually gets so much more pleasure. If people could just magically expose themselves to the increased pleasure that they would

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

experience by living better they would have no problem getting started. You have to create in your mind a future that you know gives yo

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

u much greater pleasure than you are experiencing now and realize that the only way to achieve that is to change your lifestyle.

If you

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

have type II diabetes I hope that you will take this new evidence to your doctor and find a way to improve your condition and wean your

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

self off all the drugs. Work with your doctor to increase your exercise routine, eat better, take high quality nutritional supplements a

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

nd cut back on the drugs. If your doctor is so pro-drug that they are blind to these approaches then GET A NEW DOCTOR. You deserve to li

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ve the rest of your life moving toward more pleasure and away from pain. Don't give up the fight.

Copyright (c) 2007 The Brain Code LLC

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Advice Pool - Diet, Exercise Beat Drugs at Combating Type II Diabetes

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