Advice Pool - Health and Fitness

Diabetes mellitus, or diabetes 2 for short, is a medical ailment that is connected to the abnormal high levels of glucose or blood sugar. There are so many kinds of diabetes, but what exactly is the differe

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

nce between the type I diabetes and type II diabetes? Also, what are their symptoms?

Glucose is the sugar that is contained in foods such as honey and fruits. It is also the starch that is converted throug

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

digestion. Glucose provides the energy which our body needs. Glucose is controlled by insulin. Insulin is the substance produced by the gland near the pancreas. It lowers the blood sugar level because it i

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

the body's stimulant to create the glucose.

When the glucose in the bloodstream increases, the insulin released by the pancreas regulates the glucose level. But patients diagnosed with diabetes have high

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

lucose levels that can no longer be normalized. This results to the high levels of glucose which often leads to glucosuria or glucose presence in urine.

How do you know that you already have diabetes?

Typ

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

1 Diabetes is insulin-dependent. It is also referred to as juvenile-onset diabetes primarily because the signs of the disease already show during childhood or the teenage years. In this type of diabetes, t

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e pancreas does not release any insulin because the body has already diminished the cells that produce it. The diagnosed patient therefore relies heavily on insulin treatment.

But the most common type of d

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

abetes mellitus is Type 2 diabetes. Before, it was called non-insulin diabetes. Now, it is referred to as adult onset diabetes because the signs show during adulthood. Patients with Type 2 diabetes continue

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

to produce insulin but not enough for their bodies to properly use.

The first sign of type 2 diabetes is the blood sugar level increase slowly yet surely. This is so subtle that you wouldn’t realize someth

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ng's wrong. In fact, a third of people diagnosed with diabetes had no idea that they already have the disease.

Other symptoms of Type 2 diabetes are:
- you're always thirsty
- frequent urination<

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

r> - you're always getting hungry
- immediate weight loss
- you're often stressed

Other symptoms of Type 2 diabetes include:
- cuts, bruises and infections that do not heal quickly
- b

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

urry vision
- numbness or tingling of the feet and hands
- bladder, gum and skin infections
- for women, vaginal yeast infections

Diabetes is a serious illness. In fact, it is the seventh te

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

minal disease. If diabetes is not treated it can lead to serious health problems such as blindness, kidney failure, nerve damages in the hands and feet, narrowing of blood vessels or what is commonly known

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

s atherosclerosis. If this happens, then there is more chance of a heart attack or stroke to occur.

Once diagnosed with diabetes, you have it forever; it is a chronic condition that lasts your whole life.

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ype 2 diabetes normally begins in adulthood. Generally, it hits adults over 40 years old. In most cases, it develops gradually. The ironic thing about it is that it may already be present for several years

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

rior before it is actually detected.

The treatment of Type 2 diabetes is a healthy lifestyle. That means the right diet and regular exercising in order to shed off the excess weight. If these measures fail

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

d, oral medicines can also boost the insulin production in the body. A person with diabetes must control the levels of fats in his bloodstream because if not, they are more prone to have cardiovascular dise

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ses.

Recently, a medicine called ACE or angiontensin converting enzyme has been discovered. This reduces the risk of cardiovascular complications in patients diagnosed with diabetes. It can also lessen the

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

progress of eye diseases and kidney problems.

There may be no cure for diabetes mellitus at the moment but it can successfully be controlled. The benefits of pancreas and inslet cell transplants in people

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ith diabetes are currently being observed whether this will result to the complete eradication of the disease. As soon as the symptoms of Type 2 diabetes are evident, make an appointment with your physician

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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