Advice Pool - Health and Fitness

Diabetes is a metabolic disorder in which blood-sugar (glucose) levels are above normal—either the body doesn’t produce enough of the hormone insulin, which breaks down sugar in the blood, or it cannot utilize its own insulin properly. Diabetes can cause serious health compli

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

cations including blindness, kidney failure, heart disease, and even limb loss. The good news is that if you are one of the 20.8 million Americans struggling with diabetes (type 1 and type 2 combined) there are natural approaches to help avoid these life-threatening condition

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

s.

As in almost all areas of health, exercise and proper diet can help tremendously for diabetes. That does not mean a heavy exercise regimen nor does it mean a radical weight loss. Moderate exercise and a weight lose of only 5% or slightly more can make a substantial diff

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

erence (and that holds true for those considered significantly overweight as well as those carrying a few pesky extra pounds. To achieve a 5% or more weight loss may require no more than cutting out soft drinks and taking regular walks for example. At any rate, losing 5% is

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

easily achievable with modest exercise and a sensible diet that includes plenty of vegetables and fruit (though little or no fruit juice because of its high sugar content), fermented whole grains, and getting rid of dangerous trans fats.

In addition to sensible dieting and p

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

hysical activities, the following have all shown the ability to help with diabetes:

Pycnogenol - Pycnogenol is a powerful antioxidant derived from French maritime pine tree bark and the subject of more than 180 studies over 35 years which has been shown to reduce high blood

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

pressure, LDL cholesterol and blood glucose without affecting insulin levels. Of particular note is its ability to reduce leakage into the retina by repairing capillaries in the eyes. While still largely unknown to American doctors, Pycnogenol is the leading prescription for

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

diabetic retinopathy in France.

Bitter Guord - Make a watery juice of a small Bitter Guord (remove seeds) and drink every morning. Bitter Guord also helps to clear pimples and maintain a good skin, and is good for de-worming the intestines.

Fenugreek seed - Soak fenugreek

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

seeds in about one teaspoon in water at night, drink that water in the morning and chew and eat the soaked seeds. Helps reduce blood sugar.

Green plaintain peels - Wash a green plantain and peel it, then put the peel in a jar and cover with water. Let sit overnight, and th

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

en drink this water three times a day. Lowers your blood sugar level. Keep drinking as needed and change the peel every other day and refill the jar with water.

Mullaca - Mullaca is employed in herbal medicine systems today in both Peru and Brazil. In Peruvian herbal medic

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ine the plant is called mullaca or bolsa mullaca. To treat diabetes, the roots of three mullaca plants are sliced and macerated in 1/4 liter of rum for seven days. Honey is added, and 1/2 glass of this medicine is taken twice daily for 60 days. In addition, an infusion of the

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

leaves is recommended as a good diuretic, and an infusion of the roots is used to treat hepatitis. For asthma and malaria, the dosage is 1 cup of tea made from the aerial parts of the plant. In Brazilian herbal medicine the plant is employed for chronic rheumatism, for skin

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

iseases and dermatitis, as a sedative and diuretic, for fever and vomiting, and for many types of kidney, liver, and gallbladder problems.

Agaricus Blazei Murrill (ABM) Mushroom – referred to in it’s native Brazil as “The Mushroom of the Gods” with good reason due to it’s am

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

azing immune boosting and disease fighting properties. Available in health food stores.

Alpha Lipoic Acid - In Germany, alpha-lipoic acid is an approved medical treatment for peripheral neuropathy, a common complication of diabetes. It speeds the removal of glucose from the

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

bloodstream, at least partly by enhancing insulin function, and it reduces insulin resistance, an underpinning of many cases of coronary heart disease and obesity. The therapeutic dose for lipoic acid is 600 mg/day. In the United States, it is sold as a dietary supplement, u

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

sually as 50 mg tablets. (The richest food source of alpha-lipoic acid is red meat – but to insure proper health, use lean cuts of organic beef that has not been subject to antibiotics or feed lot practices)

Cat’s Claw – Used by indigenous tribes in Peru and South America to

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

treat diabetes. Available at health food stores.

"Oleander Soup" - A carefully prepared aqueous extract of the oleander plant made according to the directions in the book "Cancer's Natural Enemy"(http://www.rose-laurel.com). Diabetics who have used this remedy report being

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

able to either reduce or eliminate medications altogether, often being able to control their diabetes with diet alone. Note: Oleander is extremely poisonous in raw form, but safe when boiled and strained according to the directions in the book.

Other Good Foods and Supple

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ments - Almonds, apples, oranges, and substances high in omega three oils (olive oil, flaxseed oil, fish oil, borage oil).

Live long, live healthy, live happy!

Required disclaimer: The author is not a qualified medical professional and the information in this arrticle has n

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ot been evaluated by the FDA. Nothing in this article is intended to diagnose or treat any medical condition. Anyone who has a medical condition should first see a qualified doctor, preferably a qualified naturopathic doctor or one who has been trained in integrative medicine

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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