Advice Pool - Health and Fitness

The complications from diabetes can have devastating effects on your health, if proper care of your health is not maintained.

Heart Disease

Diabetes is well known for being the cause of he

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

art related problems. Large amounts of sugar in the blood can cause a significant amount of damage to a body’s systems- especially blood vessels.

Unhealthy lifestyles coupled with diabetes

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

can up the chances of complications and lead to other health problems such as coronary heart disease and stroke.

Middle aged persons with Type 2 diabetes have been shown to have as much cha

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

nce of having a heart attack as the person who does not have diabetes at all but has had at least one heart attack. Hardening of the arteries, or atherosclerosis, is always a prescription fo

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

r a possible heart attack.

Take a diabetic with high cholesterol and the risk becomes that much greater. Even further, diabetics who have had one heart attack are very much at risk for anot

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

her.

Women with diabetes are much more likely to develop some sort of heart disease than women without the disease.

Warning signs of a heart attack are:

- Chest pain spreading to shoulder

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

s, neck or arms
- Chest pressure, tightness, burning or a heavy feeling in the chest
- Irregular heart rate
- Impending doom feeling
- Lightheadedness
- Fainting, na

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

sea, sweating or shortness of breath
- Sweaty skin
- Paleness
- Anxiety or nervousness

Stroke

The brain is very much dependent on oxygen to keep it alive. The brain needs a

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

network of blood vessels in which to pump oxygen rich blood. Through this network of vessels will the vital parts of the brain been feed. Without that the brain tissues will die.

Diabetics

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

are three times more likely to have a stroke than those who does not have the disease. As diabetes is more common in the African American community, this accounts for the reason that they su

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ffer a sizeable amount of the population’s strokes every year.

Ischemic stroke is characterized by an insufficient flow of blood and oxygen to the brain tissues and is the most prevalent ty

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

pe of stroke for those with diabetes. The risk for this type of stroke is peaking for younger men and older women.

A stroke is an emergency situation that requires immediate medical interve

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ntion and warrants a trip to the emergency room of a hospital. The sooner the stroke victim receives medical care, the sooner any damage can be assessed and the condition stabilized.

Warnin

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

g signs of stroke include the following:

• Numbness or weakness in a person’s face, arm or leg- especially on one side of the body
• Sudden nausea, fever or vomiting
•

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

Inability to speak or understand words and/or simple sentences
• Blurred vision in one or both eyes
• The in ability to swallow
• Dizziness
• A sudden imbalance or lac

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

k of coordination
• Loss of consciousness
• The inability to move part of the body, i.e. paralysis
• Unexplainable, intense headache

Vascular Problems of the Legs

Diabetes

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

can also cause poor circulation to the legs and feet. Vascular disease is very much a concern with diabetics. These circulatory problems can cause blood to pool in the lower parts of the bo

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

dy and is called peripheral vascular disease.

Arteriosclerosis is also a concern because it causes the blood vessels to narrow, reducing the flow of healthy oxygen rich blood to muscles in

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

the legs.

Claudication is the name for pain that results from a lack of good blood supply to calf muscles.

Leg and foot problems often land diabetics in the hospital and are the leading ca

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

use for amputations in these regions. Poor circulation makes it hard to fight infection. This is why regular check ups from doctors, and properly managing diabetes is so incredibly important

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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