Advice Pool - Health and Fitness

Diabetes causes damage to the kidneys by causing harm to the small blood vessels that make the kidneys filters. If the

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

filters get really damaged then chronic kidney disease develops. This is an incurable disease but it can be controlled.

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

An early treatment of diabetes helps by reducing the damage the kidneys receive so that when dialysis is needed the ki

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

dneys won't fail.

If identified at the right moment the physician will be able to give you a treatment that will stop

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

the disease to damage further the body. Insulin dependent diabetes (Type 1) can be diagnosed very easy and early becaus

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

e of the very rapid symptoms, so that the kidneys won't get damaged. If one has type 1 diabetes he`ll surely know it, b

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ut if he has type 2 or non-insulin dependent diabetes he may not find out about it for years because the first symptoms

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

appear after at least 3 years. This means that the small blood vessels that make up the kidneys filters are already dam

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

aged by the high sugar level in the blood. This is when one of the first kidney disease symptom appear. It is called mi

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

croalbuminuria and it is characterized by a really high volume of protein in the urine. That protein should have remain

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ed in the blood but because the damage sustained by the kidneys it reaches the urine.

After someone is diagnosed with

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

diabetes of any type, he should do regular microalbumin checking. This will help a physician to see if there's any dama

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ge on the kidneys. The doctor will give you a plan to keep. This isn't a radical plan; type 1 diabetes ill people need

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

to take their insulin while type 2 just needs to watch their diet and make allot of exercise.

If a patient has a high

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

lood pressure and diabetes in the same time he has more chances to develop kidney disease (also know as nephropathy). I

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

n this case he will be prescribed ACE inhibitors to get the blood pressure. Studies have show that ACE inhibitors are a

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

good treatment against kidney disease even if the patient has a regular blood pressure.

If someone is diagnosed with

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

diabetes it his crucial he has a healthy life. Alcohol and cigarettes will only get in the treatments way. Psychical ex

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ercise should be made as often as possible.

Not in all cases a patient diagnosed with diabetes will develop chronic ca

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ncer disease. If you live a healthy life and you follow your doctors advice you can reduce and even avoid kidney damage

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Advice Pool - Diabetes Doesn't Have to Lead to Chronic Kidney Disease

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