Tags |
|
|
Links |
|
|
Advice Pool - Chicken Pox - What You Should Know About This Infectious Disease
Chicken pox is the common name for Varicella simplex, classically one of the childhood infectious diseases caught and survived by most children.
Chicken pox is caused by the varicella-zoster virus. It starts with moderate fever and then char
Chicken pox is caused by the varicella-zoster virus. It starts with moderate fever and then char
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
acteristic spots appearing in two or three waves, mainly on the body and head rather than the hands and becoming itchy raw pox (pocks), small open sores which heal mostly without scarring.
This infectious disease has a two-week incubation pe
This infectious disease has a two-week incubation pe
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
iod and is highly contagious by air transmission two days before symptoms appear. Therefore, it spreads quickly through schools and other places of close contact.
Once someone has been infected with the disease, they usually develop protecti
Once someone has been infected with the disease, they usually develop protecti
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
e immunity for life. It is fairly rare to get the chicken pox multiple times, but it is possible for people with irregular immune systems.
As the disease is more severe if contracted by an adult, parents have been known to ensure their child
As the disease is more severe if contracted by an adult, parents have been known to ensure their child
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
en become infected before adulthood.
The disease can be fatal. Pregnant women and those with immune system depression are more at risk. Death is usually from varicella pneumonia. In the US, 55 percent of chicken pox deaths were in the over-2
The disease can be fatal. Pregnant women and those with immune system depression are more at risk. Death is usually from varicella pneumonia. In the US, 55 percent of chicken pox deaths were in the over-2
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
age group. Pregnant women not known to be immune and who come into contact with chicken pox should contact their doctor immediately, as the virus can cause serious problems for the fetus.
A vaccine has been available since 1995, and is now
A vaccine has been available since 1995, and is now
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
equired in some countries for children to be admitted into elementary school. In addition, effective medications (e.g., aciclovir) are available to treat healthy and immunocompromised persons. Calamine lotion is often used to ease itching and
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
paracetamol to reduce fever. Aspirin is not recommended in children as it can lead to Reye's syndrome.
Chicken pox is an infection that spreads from person to person by direct contact or through the air from an infected person's coughing or
Chicken pox is an infection that spreads from person to person by direct contact or through the air from an infected person's coughing or
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
neezing. Touching the fluid from a chicken pox blister can also spread the disease. A person is contagious 1-2 days before the rash appears and until all blisters have formed scabs. This may take between 5-10 days. It takes from 10-21 days af
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
er contact with an infected person for someone to develop the disease.
The blisters start as a small red papule which develops an irregular outline in the shape of a rose petal. A thin-walled, clear vesicle (dew drop) develops on top of the
The blisters start as a small red papule which develops an irregular outline in the shape of a rose petal. A thin-walled, clear vesicle (dew drop) develops on top of the
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
rea of redness. This "dew drop on a rose petal" lesion is very characteristic for chicken pox. After about 8-12 hours the fluid in the vesicle gets cloudy and the vesicle breaks leaving a crust. The fluid is highly contagious, but once the le
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
ion crusts over, it is not considered contagious. The crust usually falls off after 7 days sometimes leaving a craterlike scar.
Although one lesion goes through this complete cycle in about 7 days, another hallmark of chicken pox is the fact
Although one lesion goes through this complete cycle in about 7 days, another hallmark of chicken pox is the fact
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
that new lesions crop up every day for several days. Therefore, it may take about a week until new lesions stop appearing and existing lesions crust over.
Second infections with occur in immunocompetent individuals, but are uncommon and rare
Second infections with occur in immunocompetent individuals, but are uncommon and rare
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
y severe.
Japan was among the first countries to routinely vaccinate for chicken pox. Routine vaccination against varicella zoster virus is also performed in the United States, and the incidence of chicken pox has been dramatically reduced f
Japan was among the first countries to routinely vaccinate for chicken pox. Routine vaccination against varicella zoster virus is also performed in the United States, and the incidence of chicken pox has been dramatically reduced f
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
om 4 million cases per year in the pre-vaccine era to approximately 400,000 cases per year as of 2005.
The vaccine is exceedingly safe: approximately 5% of children who receive the vaccine develop a fever or rash, but there have been no deat
The vaccine is exceedingly safe: approximately 5% of children who receive the vaccine develop a fever or rash, but there have been no deat
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
s, as of May 2006, attributable to the vaccine despite more than 40 million doses being administered.
41 of the 50 US states require immunization for children attending government- run schools. The vaccination is not routine in the United Ki
41 of the 50 US states require immunization for children attending government- run schools. The vaccination is not routine in the United Ki
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
gdom. Debate continues in the UK on the time when it will be desirable to adopt routine vaccination, and in the US opinions that it should be dropped, individually, or along with all immunizations, are also voiced.
The CDC and corresponding
The CDC and corresponding
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
ational organisations are carefully observing the failure rate which may be high compared with other modern vaccines - large outbreaks of chicken pox having occurred at schools which required their children to be vaccinated.
Catching wild ch
Catching wild ch
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
cken pox as a child has been thought to commonly result in lifelong immunity. Parents have deliberately ensured this in the past with pox parties and similarly for some other diseases such as rubella.
Historically, exposure of adults to cont
Historically, exposure of adults to cont
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
gious children has boosted their immunity, reducing the risk of shingles.
Disclaimer: This article should not be substituted for medical advice. Please talk to a qualified professional for more information about chicken pox
Disclaimer: This article should not be substituted for medical advice. Please talk to a qualified professional for more information about chicken pox
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
HTTP = HTML link (for blogs, profiles,phorums):
<a href="http://www.advicepool.org.ua/article/241417/advicepool-Chicken-Pox--What-You-Should-Know-About-This-Infectious-Disease.html">Chicken Pox - What You Should Know About This Infectious Disease</a>
BB link (for phorums):
[url=http://www.advicepool.org.ua/article/241417/advicepool-Chicken-Pox--What-You-Should-Know-About-This-Infectious-Disease.html]Chicken Pox - What You Should Know About This Infectious Disease[/url]
Related Articles:
Blog and Search Engine Optimization Tips
Bookmark it:
|