Advice Pool - Health and Fitness

White flour contains alloxan, which is the chemical used to make flour look cle

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

an and white. Alloxan destroys the insulin-producing beta cells of the pancreas

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

It does so by initiating free radical damage to the DNA in the pancreas. Resea

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

chers believe that some people have weak defenses to free radicals in these bet

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

cells. Alloxan is so potent that researchers who study diabetes use it to give

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

diabetes to lab animals. While not everyone who eats white breads and processed

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

foods will get diabetes, the connection is clear: Alloxan causes diabetes in th

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

se genetically susceptible to the disease.

Even if you are already diabetic, y

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

u should stop eating foods that contain white flour. Studies show that certain

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ietary supplements can reverse the effects of alloxan in the animals that were

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

oisoned by it. Vitamin E effectively protected lab rats from the harmful effect

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

of alloxan. The Indian herb Gymnema Sylvestris allowed lab animals to regener

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

te insulin-producing Beta cells after a few months. Gymnema Sylvestris therapy

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

as also helped Type 1 Diabetics to decrease their insulin. In alloxan-induced d

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

abetic rabbits, blood sugar dropped almost as much with garlic as with the anti

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

diabetic drug Tolbutamide. Researchers have also used both ginseng and aloe ver

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

to support alloxan-induced diabetic mice. In people with non-insulin dependent

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

diabetes, aloe vera has been used at doses of a one-half teaspoonful 4 times da

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ly which reduced blood sugar levels at a mean average of 273 to 151 mg/dl in 14

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

weeks. This was accomplished without a change in the test subjects' body weight

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Advice Pool - Are You a Diabetic Who Has Eaten Foods Containing White Flour?

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