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The cause of Irritable Bowel Syndrome, or IBS, is unknown. However, researchers do know that IBS occurs when muscles in the intestines contract faster or slower than normal. These contractions cause pain, cramping, excessive gas, sudden bouts of diarrhea, or prolonged periods of constipation.

IBS tr

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

eatments generally focus on alleviating the symptoms and include high fiber diets or antispasmodic drugs to relieve constipation, or anti-diarrhea medications to relieve diarrhea. Other treatments include stress management techniques, psychotherapy and biofeedback. Many people turn to alternative IBS

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

treatments such as acupuncture, herbal remedies or colonics.

Listed below is a brief overview of the various IBS treatments. As with any disorder, it's best to consult with a qualified practitioner.

Acupuncture is an ancient form of healing modality used in China for thousands of years. Fine needl

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

s are inserted under the skin, along primary meridians. These meridians regulate all physical and mental processes. The Chinese believe the energy (chi) in these meridians can become blocked, flow too quickly or too slowly; resulting in illness and disease. Acupuncture can bring balance to these meri

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

dians.

Aromatherapy dates back at least 5,000 years and is considered to be one of the oldest healing methods. It involves the inhalation or absorption of essential oils directly into the body. When treating illness, only therapeutic essential oils should be used. Some IBS sufferers have found relie

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

f from IBS symptoms by using the essential oil of Chamomile.

Ayurvedic medicine is a form of traditional medicine used in India. Ayurvedic medicine is based on the belief that there are three "doshas" which control the health of the body. If any of the doshas become imbalanced, then illness will res

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

lt. Triphala is the most popular Ayurvedic herbal formula used to treat IBS. Composed of three fruits, Triphala is a laxative that cleanses and detoxifies the body, without depleting its reserves.

Biofeedback is tool used to help people learn how to better control their reaction to certain events an

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

d stimuli. In biofeedback therapy, sensors are placed on the patient's body and used to measure body processes. The sensors measure various bodily functions and results are displayed on a computer monitor in the form of graphs or sounds. This information is then used by a trained biofeedback therapis

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

t to help the patient modify or change any unusual responses.

Colonics are used to wash out waste products from the colon. Warm, sterile water is inserted into the rectum and fecal matter is expelled through a plastic tube connected to a colon irrigation machine. Because colonics induce peristaltic

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ontractions in the colon, many IBS patients are sensitive to colonics and may find them to be uncomfortable or even painful.

Enemas are used to help soften the stool and may be useful for IBS treatment for patients who suffer

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

from chronic constipation. Enemas use water or other liquids and solutions to cleanse the lower part of the colon. Health advocates claim that enemas contribute greatly to the strength of the digestive system by improving the blood circulation to the entire digestive system.

Herbalism involves the u

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

se of remedies made from the various parts of plants including leaves, roots, berries, barks and oils. Remedies are generally available in the form of tablets, tinctures, teas, and essential oils. Peppermint oil can reduce abdominal pain and distension. Fennel seed can relieve IBS spasms. Clown's mus

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ard can help restore tone to the gastrointestinal tract. Caution should always be used when ingesting herbs. Just because it is natural does not mean that it is safe. Pregnant women should avoid the use of any herbs or herbal preparations unless under the supervision of a qualified healthcare practit

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ioner.

Homeopathy is a system of medicine used to treat a variety of health conditions. The science of homeopathy is based on the Law of Similars. The Law of Similars states that "since exposure to a substance can cause specific symptoms in a healthy person; that substance -- when correctly prepared

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

as a homeopathic remedy -- can stimulate the body’s curative powers to overcome similar symptoms during illness."

Simply put, a substance which would cause a certain symptom when given in large doses; is given to a patient in very small doses and diluted many times, to treat that same symptom. Home

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

pathy is practiced in many regions of the world, including Europe, Asia, the U.K., and the U.S. Homeopathic practitioners have collected information on the use of several hundred remedies, as well as documented clinical trials. It's best to work with a qualified homeopathic physician to establish a p

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

roper IBS treatment.

Hypnotherapy is a well-established treatment for IBS. Gut-directed hypnotherapy is a special form of hypnotherapy developed for IBS and digestive disorder sufferers. It uses gut-specific treatments and suggestions aimed at normalizing bowel movements and removing pain and bloati

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ng.

Reflexology is a technique of foot and hand massage that may help to open blockages in the body's meridians. Reflexology is based on a theory that different zones on our feet and hands correspond to other areas of our body. Light pressure is applied to reflex zones corresponding to the area of t

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e body that is out of balance. There is no evidence to support that reflexology has any affect on IBS symptoms. However, many people who use reflexology claim that it helps reduce abdominal pain and episodes of diarrhea.

Yoga is a practice of discipline developed in India. Yoga focuses on physical p

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ostures, breathing exercises and meditation. Yoga can be a helpful IBS treatment, as it is known to help reduce stress. Stress often causes flare-ups of irritable bowel syndrome. Yoga may also be beneficial in treating IBS pain

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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