Advice Pool - Health and Fitness

Hypertension is the medical term for high blood pressure. If you are diagnosed with hypertension, it means that your blood pre

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ssure is too high and is putting too much pressure on the artery walls as it travels through the body. If undiagnosed or not t

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

eated properly, hypertension can cause serious damage to the arterial system, kidneys, brain and eyes. Hypertension may also r

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

sult in death, as it is the leading cause of strokes.

A person is diagnosed with hypertension if their blood pressure measures

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

over 140/90 on three consecutive measurements taken at least six hours apart from each other. Two numbers determine the patie

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

t’s actual blood pressure. The first number measures the systolic pressure. This number measures the cardiac output and tells

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

the highest level of pressure in the arteries. The second number is the diastolic pressure. This number indicated the periphe

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ral resistance and tells the lowest amount of pressure in the arteries. In other words, these two numbers comprise the range o

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

pressure in the arteries.

There are several different types of hypertension. Primary hypertension can be caused by smoking,

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ifestyle, stress, or smoking. Secondary hypertension is high blood pressure resulting from some other illness, such as congest

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ve kidney failure or heart failure.

Another form of hypertension is caused by pregnancy. High blood pressure beyond the twent

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ieth week of pregnancy is called PIH, which stands for pregnancy induced hypertension. This can lead to a condition known as p

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

eeclampsia, which can place the mother and unborn child at serious risk. It can, in rare cases, lead to the mother’s death.

I

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

you are diagnosed with hypertension, you doctor or nutritionist may discuss the DASH Diet with you. This diet is designed to

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

help people lower their high blood pressure and make healthy lifestyle changes that are permanent. This is a low fat diet that

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

requires the individual to increase the number of fruits and vegetables they eat each day. This will help the individual feel

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ull, and they will not grab for chips and other unhealthy snacks in order to satisfy a craving. While you are on the DASH Diet

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

, you are encouraged to increase your exercise schedule, which will also help you lose weight.

If diet and exercise do not low

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

r your high blood pressure, your doctors may prescribe a medication to help control your hypertension. Before you go on any me

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ication, be sure to discuss the pros and cons of the medication with your doctor. This will help you make an informed decision

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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