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Advice Pool - Gum Disease Risk Factors
Gum disease is a wide spread but silent problem. Many people do not understand the seriousness of this issue until their smiles become less attractive and their gums have receded. If that doesn't draw a pe
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
rson's attention to the situation, loose and lost teeth will.
Unfortunately, this is what it sometimes takes for a person to sit up and take notice. It's hard to be on guard against something if you don't
Unfortunately, this is what it sometimes takes for a person to sit up and take notice. It's hard to be on guard against something if you don't
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
recognize it as a problem. That is just human nature and is understandable. However, 'prevention is worth a pound of cure', as the saying goes. If you don't think gum disease or gingivitis is something you
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
need to worry about, the odds state otherwise. The Mayo Clinic website estimates that about 80% of adult Americans have some form of this disease.
Eight out of ten adults is quite a large number of peopl
Eight out of ten adults is quite a large number of peopl
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
. So this is something that virtually everyone needs to be concerned about. Here are some specific factors that can contribute to the development or intensity of an existing gum disease problem.
1. Smokin
1. Smokin
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
g - Smoking harms most of the body's tissues and immune system. You need a fairly strong immune system to combat gum disease. If you smoke or chew tobacco, you should probably stop. This is just one more f
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
om a long list of reasons to quit the use of cigarettes and chewing tobacco.
2. Clenching or Grinding the Teeth - This is a big one for some people. If you grind your teeth, you may want to get a mouth gu
2. Clenching or Grinding the Teeth - This is a big one for some people. If you grind your teeth, you may want to get a mouth gu
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
ard which can be bought at most any drug store. Ask someone if they hear you grinding your teeth while you sleep. The extreme pressures generated from clenching and grinding can weaken the supporting struc
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
ure of your teeth and gums. This can make it easier for a gum tissue infection to occur or increase the progression of an existing invasion.
3. Medications - Certain medications can affect the health of t
3. Medications - Certain medications can affect the health of t
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
he gum tissue. Whenever you pick up a medication from your local pharmacy, you should ask the pharmacist for a print out of side effects. This will be quite an eye opener to you. Look for any side effect t
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
at mentions oral health, periodontitis or gum disease in particular.
4. Pregnancy and times of hormonal change. Hormonal changes can affect your gums. In addition, a woman with an existing case of gum dis
4. Pregnancy and times of hormonal change. Hormonal changes can affect your gums. In addition, a woman with an existing case of gum dis
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
ease is seven times more likely to have a low birth weight, preterm child
5. Genetics - Studies done on identical twins seem to indicate that there is a genetic factor that comes into play with gum diseas
5. Genetics - Studies done on identical twins seem to indicate that there is a genetic factor that comes into play with gum diseas
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
. Some people are more susceptible and have to work harder to prevent plaque build-up on their teeth, especially near the gums. On the other end of the spectrum, there appears to be 2% of the population th
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
at is resistant to gum disease. This shows that what genes you inherit can have an impact on your oral health.
7. Stress affects the immune system of the body. A healthy immune system is important in figh
7. Stress affects the immune system of the body. A healthy immune system is important in figh
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
ing off infections, including the bacteria that cause gum disease. Too much stress weakens the immune system.
8. Diabetes - In general, those who suffer from diabetes are at higher risk to contract infect
8. Diabetes - In general, those who suffer from diabetes are at higher risk to contract infect
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
ions. Gum disease is an infection of the gum tissue. This is also true for any other disease that effects or compromises the immune system.
Gum disease is fairly common and even if you think you don't hav
Gum disease is fairly common and even if you think you don't hav
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
it, you very well could. Ask your dentist at every check up if you are showing any signs of gum disease. Develop superior oral care habits now and you could very well keep your teeth and gums healthy for
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
the rest of your life.
If you already have gum disease, now is a good time to take action. In addition to checking with your dentist for diagnosis and treatment, research everything you can about gum dise
If you already have gum disease, now is a good time to take action. In addition to checking with your dentist for diagnosis and treatment, research everything you can about gum dise
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
se. Before trying any alternative methods or treatments, be sure to consult with your dentist.
As I side note, something that I personally believe contributes to the overall health of my body is the very
As I side note, something that I personally believe contributes to the overall health of my body is the very
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
gentle but powerful exercises of Falun Dafa. You can find them described in detail and even watch video instructions at the http://falundafa.org/ website
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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