Advice Pool - Health and Fitness

All around the world, malaria can be a very serious problem.-especially in

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

areas where mosquitoes are plentiful, since they are one of the main source

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

s of passing the disease on. An estimated 700,000 people die each year from

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

the debilitating disease, so this is at the utmost urgency. We have all wi

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

nessed the distressing images of impoverished people in malaria-ridden land

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

s dying of the disease. Researchers have recently genetically engineered a

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

new kind of mosquito- one completed resistant to the malaria.

The test con

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ucted forced mosquitoes to feed on malaria-infected mice. Some of the mosqu

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

itoes were resistant, and those were saved. The mosquitoes that contracted

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

the malaria were thrown out of the experiment. From this singling out, scie

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

tists could study and genetically alter/breed new mosquitoes that were resi

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

stant to the disease.

The tests are relatively safe- don’t worry. The same

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

malaria that infects mice does not infect humans. For this reason, no big

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

leap and bounds have been made just yet. The scientists have begun work on

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

reeding mosquitoes to not transmit the human form of malaria- something tha

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

t will take time. But the end point could represent a huge sea change in th

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

e pattern and spread of the disease.

The tests are funded by the National

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

nstitutes of Health. The successes so far are showing some promising result

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

s, but nothing can be used as of yet to benefit mankind. The research has e

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

xpected to one day block the illness, but for now we can only wait and hope

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Advice Pool - Prevention Of Malaria On The Way?

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