Advice Pool - Health and Fitness

Mentioning the phrase drug addiction would usually make people think about illegal drugs like heroin and cocaine. But there are far more kinds of legal drugs b

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

eing dispensed daily all around the world that can potentially become a source of addiction and physiological dependence.

Pain killer addiction has been slowl

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

becoming a significant problem the past few years. In fact, in 2002, the National Institute on Drug Abuse has revealed that about 3 million teenagers aged 12

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

o 17 and almost 7 million adults aged from 18 to 25 has used prescription drugs for non-medical uses at least once in their lives. This was a surge from less t

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

an half a million in the 1980's. The more potent danger comes from the fact that unauthorized use of these substances can lead to thousands of deaths per year.

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

Pain killers are much harmful if combined with other agents such as alcohol.

The pain killer medications that can become addictive are those that belong to th

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

class of drugs called opioids. Common opioids are as follows:

- Morphine

- Hesperidins (Demerol)

- Oxycodone (Oxycontin)

- Hydromorphone (Dilaudid)

- Pro

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

oxyphene

- Hydrocodone (Percocet, Vicodin)

Opioids generally attack particular proteins all around the body, and these are called opioid receptors. They are

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ound in the spinal cord, the brain and the gastrointestinal tract. When they successfully attach to these receptors, they work by blocking the transmission of

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ain messages into the brain. This also can induce the feeling of euphoria by the stimulation of the regions of the brain that are responsible for mediation of

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

leasure sensations.

The chronic and long term use of opioids consequently lead to tolerance, meaning users must take more and more doses in order to achieve t

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

e same effects. It can also lead to physiological dependence and even addiction, wherein the body now adapts to the presence of the pain killer medication and

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ithdrawal symptoms will likely occur if the dosage is reduced or if use is stopped.

However, despite this pending danger, the use of opioids can be safe if us

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

d correctly. Most people who are prescribed the use of pain killers do not become addicted. They are actually godsend, as it relieves the chronic pain of most

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

eople who suffer debilitating conditions. But this can only work effectively if taken as instructed.

The vulnerability of a person towards pain killer addicti

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

n might be difficult to determine, as addiction and dependence develop for various reasons. But the root of the problem comes from drug misuse, such as mixing

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

t with alcohol or taking doses more than prescribed. Another type of misuse is by taking them in forms other than instructed, such as crushing them, snorting,

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

r injecting into the bloodstream, all of which bypass the drug's gradual release into the body. Children might also ingest opioids accidentally and can lead to

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

unwanted effects ad even fatalities. People who currently have addictions in other substances like alcohol, may have higher risk of pain killer addiction.

For

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

more information on prescription pain killer addiction and detailed description on its different kinds, you can check out http://www.mypainkilleraddictions.com

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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