Advice Pool - Health and Fitness

You'd have to be living under a rock or on another planet not to know about the growing controversy over steroids and the dangers of steroid use. Stero

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ids virtually ended the careers and the lives of some great athletes. And yet in spite of all the warnings and the positive proof of harmful and even d

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

eadly side effects, steroid use continues at an alarming rate. Well, maybe we need just one more wake up call to the dangers of steroids. But instead o

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

boring you with some dull facts and figures, maybe a true story will knock some sense into those who are using steroids for the purpose of getting tha

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

t "edge" that so many look for when competing in sports activities.

Two years ago, one of my best friend's kids was a promising and up and coming foot

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

all star. This kid was naturally big to begin with. At only 17 years of age he was over 6 feet and 220 pounds. Certainly he was big and strong enough t

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

o make it. He sure as heck had the talent. Well, it seems that his size wasn't big enough for him. So he got his hands on some anadrol, which is an ana

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

bolic steroid. He did not get it legally, which is a crime in itself. Just a first time offense can land you in jail for up to a year with a $1,000 fin

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

. Well, this kid wasn't lucky enough to land in jail. He ended up dead from heart failure.

This was not some sick kid with a heart condition. This was

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

a health and strong 17 year old who ended up dead from a heart attack because he took steroids. If this sounds cold and direct, I hope so.

Many years

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ago, back in the 70s, there was a program called "Scared Straight" This was a program that took inner city kids to maximum security prisons to see how

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

horrible prison life was. It was an attempt to keep these kids from turning to a life of crime. Well, we need something similar with steroid use becaus

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e the problem is out of control. My friend's kid is dead. There's still hope for yours.

For those who need the technical specifications of the dangers

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

of steroids, how about just a few for starters?

Men who take steroids actually develop breasts. When they get an erection it is very painful and their

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

testicles shrink. Their sperm count can go down to the point where they become sterile. Many also become impotent. I won't even go into the horrors th

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

t face women as it sickens me to even think about them, not the least of which is they grow beards and have their menstrual cycles totally screwed up.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

But the worst part of taking steroids is that ultimately they cause an enlarged heart and heart attacks. They run the risk of liver damage or liver ca

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ncer and many go into what is called "roid rage" where they have uncontrollable fits and can become dangerously violent. The younger you are when you t

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ke steroids, the worse it is.

I could go on, but I'm sure you've gotten a pretty grim and ugly picture of the consequences of steroid use. So if you'r

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

e taking steroids, or know anybody who is, it's time to put a stop to it as soon as possible.

I know my friend wishes he had done the same for his kid

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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