Advice Pool - Health and Fitness

Genetic and Environmental Factors

According to the National Institute on Alcohol Abuse and Alcoholism (NIAAA), a person’s risk of developing alcoholism is 60% determined by his or her genetics and 40% caused by his or her environment. Assuming that these stat

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

istics are accurate, what can be done to reduce the chances of becoming addicted to alcohol?

Genetic Causes of Alcoholism

Regarding the genetic determinants of alcoholism, those who say, “nothing can be done” are not totally correct. True, a person cannot ch

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ange his genetics. Knowing, however, that there is a history of alcoholism in a person’s family, for example, can help a person “prevent” this potential problem from ever starting if he practices total abstinence. This kind of preventative thinking is an example of a “proacti

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ve” approach to problem solving.

More Proactive Problem Solving

The following illustration, however, is an even more extreme example of “proactive” problem solving that can affect the genetic basis of alcoholism. Maria, a young lady who drinks very infrequen

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ly, starts to date a young man named Kirk. As their relationship develops, Maria starts to notice that Kirk gets drunk on a regular basis. In fact, Kirk gets intoxicated at least two or three nights every week. What is especially problematic about Kirk’s drinking is that he

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

gets angry and combative when he drinks excessively. On numerous occasions, Maria has tried to encourage Kirk to seek professional help, but each time she starts to discuss his drinking, Kirk gets extremely defensive, starts yelling at her, and then goes to a bar to drink with

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

his buddies. After a year of riding an emotional roller coaster, experiencing numerous hurtful arguments, and going through many difficult alcohol-related situations, Maria finally decides to break up with Kirk. What were the major factors for the breakup? Maria wants to ha

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

e children and can’t see having them with a violent and angry man who is so dependent on drinking alcohol. Moreover, Maria figured that since Kirk is exhibiting such irresponsible behavior in a dating relationship, he could possibly get even worse if they were to get married.

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

In this illustration, by breaking up with Kirk, Maria has stopped a negative cycle from going any further. Stated differently, by deciding to end her relationship with Kirk, Maria “prevented” the genetics part of the equation from ever becoming an issue.

Concerning A

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

lcoholism, Age Matters

Another important alcohol-related statistic articulated by the NIAAA is that the earlier a person starts drinking alcohol, the more likely she will continue to drink her entire life. This being the case, it therefore makes sense to look for way

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

that will significantly reduce alcohol abuse by teens, preteens, and by young adults.

An Environmental Framework

Employing an “environmental” approach (as opposed to a genetics-based methodology), higher education seems to be a logical starting point for way

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

s to reduce alcohol problems manifested by our youth. Indeed, since many teenagers go to college and because teen alcohol abuse IS a serious health risk, it is relevant to ask what college administrators can do to significantly reduce student alcohol abuse, especially when tee

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

nagers are some of the main “offenders.” It is suggested that the following reactive and proactive measures help address this issue.

Reactive and Proactive Measures to Help Reduce Student Alcohol Abuse

· Establish immediate consequences for excessive drinki

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ng.

· Discipline repeat alcohol abuse offenders.

· Monitor the drinking activities in the sororities and fraternities.

· Notify parents about their children's drinking activities.

· Talk to the owners of local drinking establishments so that minors and/or intoxicated st

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

dents are not served alcohol.

· Eliminate mixed messages about alcohol (for instance, removing alcohol advertisements from stadiums and from sports brochures).

· Inform and educate students about the long-term negative consequences of alcohol abuse.

· Increase the number

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

of alcohol-free social and recreational activities that are attractive to students.

Generalizing the Results

With additional effort and some more thought, it seems reasonable to think that alcoholism experts and college administrators will be able to generate

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

even more ways to effectively reduce alcohol abuse at institutions of higher education. Once this is accomplished, moreover, perhaps their findings can be adapted so that they will “work” in other institutions such as junior and senior high schools, boy scouts, girl scouts, c

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

urches, camps, and so on.

Conclusion

If a person’s risk of developing alcoholism is 60% determined by his or her genetics and 40% caused by his or her environment, it is asserted that the problem of alcohol addiction can be addressed from both genetic and env

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ironmental frameworks. Indeed, by using a “proactive” problem solving approach, the genetics part of the problem frequently can be eliminated. Furthermore, by focusing on various situational and behavioral factors, the environmental dynamics that help establish and reinforce

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

alcohol abuse and alcoholism can be significantly reduced.

Copyright 2007 - Denny Soinski. All Rights Reserved Worldwide. Reprint Rights: You may reprint this article as long as you leave all of the links active, do not edit the article in any way, and give the author credit

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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