Advice Pool - Health and Fitness

The 18-year-old high school student died on Mother's Day. Her mother spent the night before helplessly watching. Her daughter's body temperature reached 108 degrees. Her blood cells boiled. She bled from her m

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

outh. Was it a rare tropical fever that had caused such a horrible death? No. It was a little tan tablet called PMA.

Overview

Paramethoxymethamphetamine, or PMA, is an illegal synthetic hallucinogen with eff

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

cts similar to Ecstasy. PMA is made in clandestine laboratories. It has seen limited use since the 1970s, but has recently become popular with teenagers and the rave culture. The drug is usually sold in a tabl

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

t form with the Mitsubishi diamond emblem stamped into it. Most PMA tablets are tan, and are a little bigger than an aspirin.

Hidden Danger

The dance drug business has never been better. Every year more and

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ore high school students are lining up at rave club doors. Once inside dance drugs such as Ecstasy, GHB, and Special K are easily purchased. Stricter Government control of chemicals used to make Ecstasy have m

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

de them expensive and difficult to buy. Illicit drug chemists and manufacturing operations sought out alternatives. PMA was the answer.

Ecstasy is the most popular dance drug. Ecstasy's so called pleasant eff

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

cts, and its appearance, are similar to PMA. The similarities end here. Most dance drugs raise body temperature, but PMA can send it soaring to 108 degrees. Since the chemicals to make PMA are easier to find,

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

t's cheaper to make. PMA is sold as Ecstasy. PMA tablets can be made for less than a dollar, whereas Ecstasy tables cost two to three dollars to make.

Drug dealers do not care if they hurt or kill teenagers,

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

s long as they are making money. They rely on fast transactions and dimly lit corners inside rave clubs to mask their deadly dealings. By the time a teenager realizes he or she has made a serious mistake, it i

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

too late. Depending on purity and dosage, the teenager could spend the rest of his or her life boiling to death internally on a rave club floor. Having made their money, the dealers would have moved on to ano

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

her rave club before anyone knew what happened.

Purity and dosage amount varies from tablet to tablet. Even tablets from the same batch of PMA vary. One tablet will provide a user with the experience he or sh

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

e is looking for, while the next one out of the bag will kill the unlucky teenager who chooses it.

2-CB was an attempt to get around the laws banning Ecstasy. The effects are similar, but the manufacturing pr

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

cess produces hard to control dosages. 2C-B usually comes in pill form, but is sometimes available in powder. Technically speaking it isn't a "new" drug, since it was developed in the mid seventies. It is new

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

o the rave crowd, and wasn't put on the DEA's Schedule One list until the mid nineties.

As the chemicals to make Ecstasy and Ecstasy-like drugs become harder and harder to find, other drugs will find their wa

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

into rave clubs and your school. Yaba is the latest thing in some parts of the country. Like many drugs before it, Yaba will find its way into every city and school.

Yaba is Methamphetamine, however, it has

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

een know to produce disturbing and realistic hallucinations. Ravers call these "eyelid movies." This drug is particularly dangerous because it is simple to make. You can find just about everything you need to

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ake it around the corner at your grocery store.

The main ingredients are salt, household cleaning products, distilled cold medicines, and lithium from camera batteries. Any kid with a D or better in chemistry

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

can follow the formula using two of his mother's casserole dishes. What Can be Done?

The police will continue to take small amounts of Ecstasy, PMA, 2C-B, and Yaba off the streets. Lucky teenagers who survi

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e overdoses can undergo drug treatment. But that won't make much of a difference. What will make a difference and save young lives are parents like you. Educate yourself about Ecstasy, PMA, 2C-B, and other dru

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

s. Then educate your kids. You must make a difference.

Visit the author’s free blog for parents =>http://parentsbattleplan.blogspot.com

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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