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Drug abuse is a most divisive force within a family unit. It causes people to lie to those that trust them, to

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

use violence against those that love them and above all, to loathe themselves. In many cases the abuse of drugs

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

goes on for many years, causing an ingrained type of damage that becomes a feature of daily life. Yet amidst t

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

he pain and suffering that is caused by drugs, there often remains an inability for individuals to fully heal t

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

emselves. In fact says that the incidence of drug abuse amongst children of drug addicts remains disproportiona

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

tely high, in spite of first hand experience with the devastating disease. This fact clearly outlines the need

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

for and the significance of expert rehabilitation programs that counters the disease to the same extent that dr

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ug abuse has negatively impacted the family.

There are a variety of methods and programs that exist with regar

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

to drug rehab programs but the priorities of almost all drug rehab programs are defined by the level of abuse

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

of the drug addict. The process of successful drug rehab programs is usually based upon a series of fundamental

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

needs which are designed to:

-Allow the immediate effects of the drugs in your system to dissipate
-Safe

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ly detoxify the body and remove lasting traces of drugs from the body
-Avoid relapse by undergoing individ

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

al counseling
-Identify the things that may trigger a relapse
-Undergo family or marital counseling

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

as appropriate

The last point which relates to family and marital counseling can be extremely significant for

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

the purposes of breaking a lasting cycle of abuse. Most rehab programs are keen to point out the need for famil

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ies to tackle drug abuse and agree that the role of family and friends as a means of support cannot be overstat

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

d. Hand in hand with this issue is the need for individual members of the family to be reconciled with the pain

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

of their experiences. Family members simply cannot provide a supportive network for recovering addicts if they

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

are continuing to harbor resentment or unresolved issues that stem from the drug user. Secondly, the chances o

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

f forming a multi-generational pattern of drug abuse are far greater if family reconciliation is not undertaken

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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