Advice Pool - Health and Fitness

Millions of Americans are affected by sinusitis every year, much more than in the years before discovering antibiotics. Thoug

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

h, ant biotherapy still remains the best method to cure SOME of the sinus infections, especially those produced by bacteria.

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

Oral and local corticosteroid decongestants can ease the inflammation of sinus and nasal membranes and antihistaminic medicat

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ion reduce symptoms in case of allergic sinusitis. But chemical medication alone is not going to cure and prevent sinusitis f

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

om reoccurring. Home treatment and care must prevent the swelling of the membranes and assure their anatomical and functional

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

health.

The mucus membranes of the nose passages and sinus cavities can be irritated by dry or cold air, pollution, allergie

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

s or banal colds. When this occurs membranes get swollen and the cilia meant to evacuate mucus and foreign bodies slow down.

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

hills are thin hairy particles localized on the terminal side of nasal linings. Mucous glands are also stimulated to kill bac

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

eria by secreting more mucus.

Because of the inflammation, the mucus and bacteria are trapped inside the sinuses and infecti

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

on occurs.

Most common sinusitis symptoms are:
1. Cold or flu signs last longer than 3 days
2. The patient feels

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

discomforting pressure around eyes, forehead and cheeks
3. Pain in the upper jaw
4. Weakness and tiredness

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

5. Small amounts of mucus slip down the posterior side of the throat

Preventing sinusitis means avoiding excessive quantiti

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

es of mucus to be secreted and caring for the structure and function of cilia. This is how you can prevent and also, if occur

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ed, treat symptoms of sinusitis:

1. Keep you body well hydrated by drinking soups, hot teas or any other hot liquids.

2. We

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

l hydrated mucous membranes help the movements of the cilia and make the elimination of mucus easier. Hot coffee is not such

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

a good medication as is contains caffeine.

3. Always carry tea or apply for hot water while traveling by plane, as dry air d

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

mages the sinus membranes; these must be kept humidified all the time.

4. Apply warm towels on your face for about 5 minutes

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

three times a day. Warm water and steam will ease your circulation and cilia moves.

5. Periodically irrigate sinuses through

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

an in-and-out circuit of salty water on low pressure. Pharmacies offer you Sinus irrigators and Hydro Nasal Pulse to help yo

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

irrigate your sinuses correct and painless. These devices are easy to use and the pulse of water is gentle with your sinuses

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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