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Advice Pool - Heartburn - Is Glutamine a Cure?
The relief and treatment of heartburn, acid reflux, and GERD is a huge billion-dollar-a-year market, according to Tamas Bartfai, director of the Harold L. Dorris Neurological Research Center. Bartfai has had decades of experience as a consultant and executive
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
in the Pharmaceutical industry, and has consulted with companies that are developing costly treatments for this common ailment.
With so much money being spent on medications to relieve heartburn and its companions, you would think at least one medication wo
With so much money being spent on medications to relieve heartburn and its companions, you would think at least one medication wo
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
ld be a cure. Sadly, this does not appear to be so. Heartburn medications seem to do nothing more than relieve symptoms. Some attempt to neutralize stomach acids. Others "turn off the pumps" that manufacture stomach acids.
The pharmaceutical community seems
The pharmaceutical community seems
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
o offer nothing that will cure heartburn.
Glutamine for Heartburn
Glutamine for heartburn may be the answer. More specifically, L-glutamine for heartburn. L-glutamine for heartburn may not only be a cure, but be far less costly than other medications
Glutamine for Heartburn
Glutamine for heartburn may be the answer. More specifically, L-glutamine for heartburn. L-glutamine for heartburn may not only be a cure, but be far less costly than other medications
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
For example, In the U.S., L-glutamine can be purchased for about 5 cents per capsule. The prescription medication that "turns off the pumps" costs about $5.44 per capsule - at discount prices.
Why might glutamine be good for heartburn?
Cause of Heartbu
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
n
Heartburn appears to be a muscular problem.
Despite the pharmaceutical community's emphasis on acids, the real cause of heartburn is a weakness in the lower esophageal sphincter (LES).
A sphincter is a circular band of muscle like a ring around a bod
Heartburn appears to be a muscular problem.
Despite the pharmaceutical community's emphasis on acids, the real cause of heartburn is a weakness in the lower esophageal sphincter (LES).
A sphincter is a circular band of muscle like a ring around a bod
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
passageway or opening. If you were teaching children about a sphincter, you might place a ring around one finger to illustrate.
The task of every sphincter is to relax or tighten as needed to open or close a natural body opening or passageway. If you made y
The task of every sphincter is to relax or tighten as needed to open or close a natural body opening or passageway. If you made y
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
our illustrative ring of elastic, you would tighten and relax the elastic to show sphincter action.
1. A cow's teat has a sphincter at the lower end. It relaxes to allow milk to flow, and tightens to stop the flow.
2. The human bladder has an involuntary sp
1. A cow's teat has a sphincter at the lower end. It relaxes to allow milk to flow, and tightens to stop the flow.
2. The human bladder has an involuntary sp
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
incter at its neck. It relaxes to allow urine to flow, and tightens to stop the flow. A voluntary sphincter at the end of the urethra does the same.
3. An anal sphincter tightens to hold back waste, and relaxes to pass waste.
4. The lower esophageal sphinct
3. An anal sphincter tightens to hold back waste, and relaxes to pass waste.
4. The lower esophageal sphinct
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
r (LES) relaxes to allow food to enter the stomach, and tightens to keep food and acid from flowing backward into the esophagus. It should prevent heartburn.
Weak Sphincter Problems
If the sphincter in any of the above becomes weak, problems can occu
Weak Sphincter Problems
If the sphincter in any of the above becomes weak, problems can occu
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
.
1. A milking machine can make a cow's sphincter remain relaxed for two hours. This allows bacteria to enter the teat, and can result in mastitis.
2. A weakness in the bladder sphincter can cause urine to leak against your will.
3. When the anal sphincter
1. A milking machine can make a cow's sphincter remain relaxed for two hours. This allows bacteria to enter the teat, and can result in mastitis.
2. A weakness in the bladder sphincter can cause urine to leak against your will.
3. When the anal sphincter
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
weakens, fecal incontinence can occur.
4. A weakness in the LES allows stomach acids to reflux, flow backward into the esophagus. This causes heartburn.
When sphincters other than the LES weaken and cause problems, attention is turned to strengthening the w
4. A weakness in the LES allows stomach acids to reflux, flow backward into the esophagus. This causes heartburn.
When sphincters other than the LES weaken and cause problems, attention is turned to strengthening the w
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
ak sphincter. The cow's sphincter is often subjected to cold after milking to tighten the muscle band. Exercise can tighten both weak bladder sphincters and weak anal sphincters. Biofeedback, electrical stimulation, and certain drugs also can be used to tight
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
n these two sphincters.
Interestingly, none of these approaches seems to be used for the LES. Heartburn treatments address the symptoms, but neglect the weakened sphincter, which is the real problem.
Can Glutamine for Heartburn Help?
Glutamine for
Interestingly, none of these approaches seems to be used for the LES. Heartburn treatments address the symptoms, but neglect the weakened sphincter, which is the real problem.
Can Glutamine for Heartburn Help?
Glutamine for
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
heartburn may be a solution.
Glutamine is an amino acid. Just as other amino acids are important constituents of proteins, so is glutamine. Glutamine occurs naturally in foods that are high in protein: beans, dairy products, fish, and red meat.
Glutamine as
Glutamine is an amino acid. Just as other amino acids are important constituents of proteins, so is glutamine. Glutamine occurs naturally in foods that are high in protein: beans, dairy products, fish, and red meat.
Glutamine as
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
a supplement is used by weight lifters, body builders, and other athletes who want strong muscles. Glutamine as a supplement is also used to alleviate muscle cramps and pain, especially in older people. By replenishing the amino acids in the body, muscles are
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
strengthened and pain relieved.
Glutamine has been shown to increase the body's ability to dispose of damaged cells, and produce new cells. Glutamine is a powerful antioxidant, too. As such, it helps protect body cells from free radicals. Glutamine heals muc
Glutamine has been shown to increase the body's ability to dispose of damaged cells, and produce new cells. Glutamine is a powerful antioxidant, too. As such, it helps protect body cells from free radicals. Glutamine heals muc
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
us membranes, including the lining of the esophagus that is being damaged by heartburn.
It is thought by some that glutamine for heartburn might strengthen the LES, improving its ability to tighten properly. This might completely prevent heartburn, acid refl
It is thought by some that glutamine for heartburn might strengthen the LES, improving its ability to tighten properly. This might completely prevent heartburn, acid refl
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
x, and even GERD.
Glutamine for heartburn could possibly be a partial, if not a total cure.
Until heartburn, acid reflux, and GERD are understood and treated as the muscular problems they seem to be, physicians will continue to prescribe relief and treatmen
Glutamine for heartburn could possibly be a partial, if not a total cure.
Until heartburn, acid reflux, and GERD are understood and treated as the muscular problems they seem to be, physicians will continue to prescribe relief and treatmen
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
s that address only the symptoms.
Disclaimer: The author does not sell glutamine in any form, nor will she profit from sales of glutamine for heartburn. The author is not a medical professional and offers this information for educational purposes only
Disclaimer: The author does not sell glutamine in any form, nor will she profit from sales of glutamine for heartburn. The author is not a medical professional and offers this information for educational purposes only
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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