Advice Pool - Health and Fitness

Eating habits can change your life into a healthy one, but can also lead you to anorexia or bulimia. It all depends on the healthy or dis

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ordered eating habits. Media shows us all kind of diets and exercises confirming that losing weight and calorieshas become an obsession

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

even though they can lead to illness, with not so pleasant consequences.

Up to 4 percent of females suffer from anorexia. Sings of anore

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

xia include: - fear for weight gain and body fat - great ambition in losing more and more weight - mis perceptions of weight

Anorexic

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

persons that deny the food do not realize the danger they are exposing to and they keep seeing themselves as overweight even though they

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

are incredibly thin.

The symptoms of anorexia are:
- considerable weight loss; refusal to keep a normal weight according to age an

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

d height
- deliberate choosing to skip meals
- eating especially non-fat
- often weighing
- visible food restriction

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

and self-starvation
- obsession with continuous exercise
- obsession with weight and complaining of weight problems
- is

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

olation. Fear of eating around and with others
- wearing big or baggy clothes or dressing in layers to hide body shape and/or weight

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

loss
- dizziness and headaches
- loss of menstrual cycle
- lack of sexual desire

Two types of anorexia (combined or not

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

with bulimia) are known:
Restricting Anorexia - The first type of anorexia is found at those anorexics who severely limit their cal

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

oric intake and/or who exercise to excess to lose weight. Binge-Eating/Purging Type: The second type of anorexia is found in those anore

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

xics who eat in binges and then purge the body of the ingested food either by self-induced vomiting, the ingestion of large quantities of

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

laxatives, the overuse of diuretics and enemas to rid the body of food.

Eating disorders also have a treatment that in most of the case

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

s has beneficial results over the body weight and health. The complexity of anorexia requires appropriate medical care meaning psychologi

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

cal advice, nutritional counseling and sometimes medication. After the medical treatment the anorexics should have restored their lost

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

weight but they should also be psychologically remounted, being well known their need of rehabilitation.

Treatment is not the most wante

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

d thing at an anorexic, in most of the cases they do not even admit that they are ill. When it comes to the treatment the anorexics stron

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

g opposition can lead to a hard psychological work which only a crony could take to an end.

Depending on the case, a short or long term

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

treatment is needed. In most of the cases the long term treatment involves all main processes including especially psychological advisory

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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