Advice Pool - Health and Fitness

If you smoke, or use any form of tobacco, improving your posture while you eat isn’t going to do much for your condition. Why? Smoking/nicotine is a direct contributing factor t

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

o acid reflux and to chronic heartburn caused by gastroesophageal reflux disorder (GERD). Therefore, engaging in any tobacco use – cigarettes, cigars, pipes, snuff and chewing to

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

bacco – can not only become a literal pain in the chest, for GERD sufferers it can even disrupt sleep and interfere with your lifestyle.

The following are six ways in which smoki

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

g directly affects acid reflux:

1. Decrease in saliva production - Cigarette smoking inhibits saliva production, and eats up most of the bicarbonates within the saliva produce.

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

Bicarbonates help neutralize stomach acid, and saliva works to coat the oesophagus to lessen the effects of acid that refluxes up from the stomach. Saliva also helps to wash acid

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

in the oesophagus back to the stomach.

2. Increase in acidity – Nicotine encourages the production of stomach acid.

3. Bile salt movement – Smoking appears to encourage the move

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ment of bile salts to the stomach from the intestines. Stomach acids are even more harmful when bile salts are present.

4. Direct injury to the oesophagus – Smoking can cause di

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

rect harm to the oesophagus by making it vulnerable to acid reflux injury.

5. Impair LES functioning – Nicotine can lower the pressure in the lower esophageal (LES) which can cau

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

e it to become weak and relaxed. LES is the valve that resides between the oesophagus and the stomach. The decrease in pressure can cause the LES to relax inappropriately, allow

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ing stomach acids and enzymes to be thrust back into the oesophagus.

6. Decreased gastric motility – It has been discovered in studies that people who smoke have reduced gastric

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

otility while they are smoking. A decrease in gastric movement can lead to poor digestion due to the fact that it takes a longer for the stomach to empty.

As you can see, there

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

are plenty of reasons why smoking can cause and make acid reflux worse. That being said, it shouldn’t come as a surprise to you that the best treatment a tobacco user can do to h

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

elp their condition is quit.

Of course, quitting smoking isn’t as easy as we think or would like it to be. An addiction to nicotine is a hard habit to kick, especially if you’ve

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

been smoking for many years, hang around others who smoke, and enjoy it. However, smoking, like any addiction, can be overcome. The only trick is, in order to quit smoking, you

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

have to want to.

There are many different quitting strategies you can consider. Therefore, if you find quitting through your own methods is difficult, consult your doctor for ot

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

er options. Also, many people who want to quit smoking find support groups to be very helpful.

Does quitting smoking really help your heartburn?

It is believed by many medical

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

practitioners that for most acid reflux sufferers, quitting smoking will likely allow them to get better fast. However, some practitioners believe that quitting smoking will only

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

provide modest relief.

Nevertheless, all medical practitioners agree that quitting smoking is a good idea regardless if it helps your acid reflux or not. After all, even if you

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

see little change in your experiences with heartburn, quitting smoking greatly reduces your chances of developing serious diseases such as cancer, heart and lung disease.

In addi

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

tion, don’t forget that smoking isn’t the only cause of acid reflux. Thus, if you are not seeing improvement after quitting, it’s time for you to take a careful look at your diet

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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