Advice Pool - Health and Fitness

Take the case of 17 year old Kerry, whose boyfriend casually mentioned to her that he is upset over her being overweight and that all his friends make fun of her. Kerry, who in

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

reality was only chubby, was pretty hurt and started losing her self-esteem. She soon went into guilt pangs for being over-weight and went on a crash diet, skipping breakfast,

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

having only a fruit or two for lunch and slice of bread for dinner. She was petrified of gaining weight and losing her boy friend. Slowly and gradually she became a victim of a

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

isorder called anorexia nervosa.

The ideal image of a woman's body has changed radically in the past years. Like Kerry, most teenage girls struggle to feel good about their bod

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ies. They tend to emulate models on glamorous magazine covers and hoardings without realizing the ill effects of it on their health.

Anorexia nervosa is an eating disorder cent

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ed of an obsessive fear of weight gain. Approximately 95 per cent of those affected by anorexia nervosa are female, but males can develop the disorder as well.

Causes:

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

. Psychological factors such as fear of sexuality at this age. Past negative experiences, perceived loss of control in some aspect of life can lead to anorexia.

. Families that

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

are over-protective or focus on over-achievement can produce an anorexic family member.

. Constantly criticizing one's own body and appearance combined with low self-esteem.

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

Societal pressures to look and behave in certain manner at an adolescent.

. Certain personality traits like perfectionism, approval -seeking behavior, and obsessiveness are as

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

sociated with this disorder.

There is a possibility of genetic pre-disposition that usually becomes apparent at the time of puberty.

Symptoms:

. Excessive dieting, exe

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

cising usually beyond a reasonable control

. Significant weight loss.

. Self-perception that is grossly distorted and weight loss that is not acknowledged.

. Avoidance of soc

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ial gatherings where food is involved.

. Weighing oneself several times in the day and focusing on the smallest fluctuation.

. Misuse of laxatives, diuretics or enemas

. Decr

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ease in attention spans and concentration.

. Developing of food rituals that allow for eating very little, eating in secrecy, eating food in certain order, excessive chewing.

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

Disturbed sleep leading to fatigue during the day.

Must Read: 10 Effective tips to lose weight on hips and thighs at http://www.weightloss-health.com/slim_thighs_hips.h

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

tm

Effects:

. Girls may experience loss on menstrual cycles (amenorrhea). Disturbances in the menstrual cycle can affect not only fertility but also bone density growt

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

.

. Muscle loss and weakness.

. Lowered resistance

. Digestive problems such as constipation

. Severe dehydration, which can result in kidney failure.

. Feelings of guilt a

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

nd depression.

. Isolation from friends and family.

. Brittle hair and nails

. Dry and yellow skin.

. Mild anaemia, swollen joints and light-headiness.

. Overuse of laxativ

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

es.

. Changes in kidney function, resulting in potassium deficiency, increased or decreased urination.

Must Read: Workout and Exercise schedule for Women Weight Trainin

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

at http://www.weightloss-health.com/woman%20muscle%20exercise.htm

Treatment:

. The primary goal is to ensure a person's physical health, which involves restoring a hea

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

lthy weight. This may require hospitalisation.

. Once the physical condition is stable, intensive psychotherapy needs to be put in place.

. Behavior therapy.

. Family therapy

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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