Advice Pool - Health and Fitness

A new study from the Medical Research Institute in Wellington examined 62 cases of DVT (Deep Vein Thro

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

mbosis) and found that 34% of them were office workers who had spent a long time sitting at their desk

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

. Although 34% may not sound like a very significant number, it is larger than the percentage of peop

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

e who developed DVT on while on long flights.

The office workers at greatest risk were those who spen

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

t 14 hours a day at their desk, spending 3 to 4 at a time in their chair without standing up.

Accordi

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

g to HealthDay, “DVT is the formation of a blood clot in a deep vein -- most commonly occurs in the le

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

gs. The clots can break free and travel through the bloodstream to the lungs, heart or brain and cause

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

breathing problems, chest pain, or even death from a stroke or heart attack.

The study found that the

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

two most common jobs to contract DVT are IT specialist and call center receptionist.

Healthwise sugg

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

sts these steps to prevent DVT:

•Taking anticoagulants to prevent a blood clot that can develop after

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

some types of surgery. They are also used in people who have a high risk of developing blood clots, s

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

uch as those who have had previous clots.

•Exercising your lower leg muscles to improve circulation i

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

your legs. Point your toes up toward your head so that the calves of your legs are stretched, then re

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

lax. Repeat. This exercise is especially important to do when you are sitting for long periods of time

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

•Getting up out of bed as soon as possible after an illness or surgery. It is very important to get

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

moving as soon as you are able. If you cannot get out of bed, do the leg exercise described above ever

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

hour to keep the blood moving through your legs.

•Using special stockings called compression stockin

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

gs to help prevent deep vein thrombosis if you are at an increased risk.

For more related articles or

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

to subscribe to our feed please visit this Consumer Advocacy website for more information on ordering

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

from an online no prescription pharmacy

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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