Advice Pool - Health and Fitness

I must be out of my mind because today I'm going to tell you not to do lunges - one of the most commonly recommended multi-muscle mov

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ements - an exercise that is ubiquitous in fat loss and muscle-building programs.

But there are times when lunges are not appropriat

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

.

Today I witnessed a perfect example of someone that should not be doing lunges. As I was in the gym doing Prisoner Forward Lunges

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

nd warming up for a 20 minute Upper Body workout, along came a lady and lunged down beside me, falling all over along the way.

With

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ach repetition she would fall to one side or the other, twisting her body viciously over her knee (which I'm surprised she didn't inj

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

re). She simply had no co-ordination to be doing the exercise, let alone to be doing it holding the dumbbells she had in each hand.

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

That my friend, is the perfect example of someone who shouldn't do lunges. And I know that many of you can't do lunges because of sor

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

knees and weak muscles, as you've emailed me for replacement exercises. So let's run through my progression of lower body exercises

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

hat will help you get better results from more appropriate exercises and without hurting your knees.

We'll start on the mat and work

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

our way up to standing exercises - just like you should if you are a beginner.

Here's our list of lower body exercise progressions:<

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

r>

2-Leg Hip Bridge/Extension
2-Leg Stability Ball Curl
2-Leg Hip Bridge/Extension on Ball
1-Leg Hip Extension
W

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

all Ball Squat
Bodyweight Squat
Prisoner Bodyweight Squat
Y-Squat
Belza Split Squat
Split Squat
Revers

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

Lunge
Forward Lunge

(NOTE; Here's the key...Everyone should master the split squat first before doing lunges. Because your

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

feet never leave the floor, the exercise is less difficult. Do this instead of lunges if you have balance problems. This will help yo

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

avoid sticky situations like the woman in the gym today.)

Once you've mastered the basic split squats and lunges, you can then move

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

onto 1-Leg Deadlifts, Bulgarian Split Squats, and 1-Leg Squats and so on. There are dozens of lower body, booty-building, hamstring-h

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

elping exercises you can do without weights.

P.S. Here's how my workout went today...and I was in and out in less than 20 minutes.

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

otal Body Bodyweight Warmup (where I thought up two new push-up exercises for future bodyweight workouts)

Superset #1
Chin-ups<

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

r> DB Shoulder Press

Superset #2
Dips
EZ-Bar Biceps Curl

Superset #3
Eccentric Cable Lateral Raise
DB

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

Hammer Curl

Again, all in 20 minutes.

Follow the right progression for safety and results in your fat-burning exercise workouts

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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