Advice Pool - Health and Fitness

Each and every day it seems like a new diet pops up. For the most part, they are fads, although

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

some diet plans last longer than others. But what happens with nearly every diet is that peopl

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

realize, in the long run, that the diet simply doesn't work.

Sure, you can lose a few pounds

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

at first with these diets. But what happens a few months down the road? More often than not, yo

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

gain back all of the weight (or you even gain back more than you lost originally). It's someth

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ng of a yo-yo effect. The cause of it is often that diets force you to deprive yourself of some

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

thing. In the short term, that works. But in the long run, it is counter-productive.

Your body

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

does not react well to the typical diet, which usually involves some form of starvation. When y

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

u starve your body, it goes into a survival setting. This causes your body to store fat, becaus

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

e your body thinks food won't be coming very often, so it needs to store whatever it gets. Anot

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

er added effect of a diet is that your body's metabolism slows down, making it that much harder

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

for you to burn calories (and that fat that you are building up). Diets also starve your muscle

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

, which causes you to lose any toned look you have and also causes your body to burn fewer calo

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ies (having muscle causes your body to burn calories).

So what's the solution?
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

Well, the answer itself is simple. But it is not an answer that most people like. The solutio
t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
n involves two things: one eating healthy foods and exercising regularly. You don't have to sta
ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust
ve yourself or eat foods without flavor. And you don't have to train like an Olympic athlete.

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
at natural foods and get some exercise. If you sit on the couch and watch television each night
.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
, mixing in some sit ups during commercial breaks might be a good start. Better yet would be ta
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip
ing a walk around the neighborhood in the evening or going for a job in the park on the weekend

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Advice Pool - Why Diets Don't Work

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