Advice Pool - Health and Fitness

Whether you are an elite athlete or are a fitness junkie chances are you are looking for as much performance as you can get from your performance programs. There are several thi

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ngs to consider when designing your programs so that you are making the progress that you want.

Warm-up

First thing to consider is your warm-up. What does your warm-up consist

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

of? Does it warm-up the entire body? Are you only doing static stretches in your warm-up? Have you considered doing some cardiovascular work into your warm-up besides treadmill

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

or stationary bike training? A proper warm-up is designed to increase blood flow, increase internal temperature, dynamically stretch your muscles, increase firing rate of muscle

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

fibers and much more. If your warm-up is not addressing these issues then you might want to consider upgrading your warm-up. Gone are the days where you run for several minutes

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

on a cardio machine or simply run for endurance to warm you up. Gone are the days where unskilled coaches simply stretch tell you to stretch your muscles statically without any

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

egard to warm-up. Actually, it has been shown in athletes that static stretching before warm-ups can slow you down. The best warm-up in my opinion that I have ever seen and it i

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

s what I warm myself up with is a dynamic warm-up such as the one used by the Parisi speed school. www.parisischool.com.

Exercise selection

Depending on what your goals are yo

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

have to take into account the exercises that are going to give you the highest returns on performance. For example, if I wanted to increase my speed then I would design my prog

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ram to include sprints such as 10, 20, 40, or 100 yard dashes and have them timed. In addition, to supplement that I would consider adding exercises that improve the motor unit

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ecruitment to fire off fibers as fast as possible. As the demand increases, you have to take into account that more fibers are going to be recruited to support the activity. The

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

higher and longer the activity the more fibers will be recruited. Same goes for fitness performance. If your goal is to improve cardiac function then it would behoove you to im

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

lement exercises to support those goals.

Volume and intensity

Once again, if your goal is to improve cardiac functions then your intensity of activity is going to have to be i

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

mportant to make those improvements. Gone are the days when runners would simply log in long miles to gain athletic performance. Runners now are doing high intensity training at

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

high explosive muscle fiber firing rates. Once again, if your goal is improve performance then more muscle fibers will be required to sustain those intensities. Volume of exerci

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

se is important because in some cases more is not always better. For example, how is doing only endurance training going to improve daily performance? Most of our daily performa

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ce requires short bursts o energy. You might need to pick something off the ground or reach for something off the kitchen cabinet. Getting your butt off the chair is an example

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

of high explosive fibers firing for limited amounts of time. How much time does it take to do those activities I just mentioned? Maybe less than 5 seconds? Does it makes sense h

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ving high volumes of endurance training if your activities are high intensity and are of short duration? I think its obvious.

There you go. Consider a proper warm-up detailing

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

those key points into your athletic or fitness program when designing one. Make sure that your intensities and volumes are supporting those goals you want into your program.

Ca

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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