Advice Pool - Health and Fitness

Lots of people come to me with sciatica, and so I’ve been doing some research on the subject. It was really interesting, so I thought I’d write an brief article about it. I’ve missed ou

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

t all the long Latin words that describe it in Doctorspeak as I could neither spell nor pronounce them!

Just about everyone knows what the term “sciatica” means. Mention the word and p

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

eople start grimacing and rubbing the backs of their legs…most of us have felt that awful, stabbing pain at one time or another. Like a bolt of lightning, sciatica makes you yelp and st

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

p whatever you’re doing! Luckily for me , the only times I ever experienced it was during pregnancy, but I know people who are plagued by it, and it’s no joke. Actually, neither’s preg

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

nancy. Nothing natural about childbirth is what I say!

Sciatica is actually a set of symptoms, rather than a diagnosis in itself, and can be caused by several things…some not serious a

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

d some very serious indeed. This is why, if you get sciatica, you MUST get it checked out by a health professional (doctor, physiotherapist or chiropractor) before you

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

try and self-treat. The cause could be anything from a tight muscle in your bottom to a slipped disk or even, at worst case scenario, a tumour. That last is rare, by the way. Thankfully

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

.

When people ring me to book a place in any of my Pilates classes, I always ask them about back and leg pain on the phone…any mention of sciatica-type problems and my ears prick up li

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

e a hound’s and I insist they get medical clearance before I accept them. I’ve lost a few potential clients that way, but nothing’s worse than someone turning up for their first class a

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

nd gaily announcing that they sometimes get “a bit of leg pain” which causes numbness in their toes…At which point I lose the will to live!

The sciatic nerve is the longest in the enti

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

e body and runs roughly from the middle of your spine down through your buttock and right down the back of your leg. Any pressure on it anywhere down its length can cause the stabbing a

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

che of sciatica. Without getting too technical (because we’re into medical territory here) there are four main causes of sciatic pain:

Slipped Disc

When you have a he

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

rniated (slipped) disc in your lumbar spine – your lower back – this causes pressure in the sciatic nerve, which is close to the spinal cord. So you have the double misery of lower back

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

pain and sciatica too. A similar thing can happen with age-related wear and tear to the spine. Maybe there’s something to be said for being a Borg. Or a Cyberman. Then again, maybe not!

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

Stenosis

This is a narrowing of the spinal canal, often associated with age (though sometimes pregnancy can cause it). Again, pressure is put on the sciatic nerve, r

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

sulting in pain being felt in the back and/or leg.

Piriformis syndrome

The piriformis is a muscle in your buttock which helps to turn your thigh outwards. It can get

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

very tight in people who sit a lot…long distance drivers and people who are desk bound for long periods. The sciatic nerve runs under this muscle – in some people it goes through the mu

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

scle – and can get irritated. This is not true sciatica, but certainly feels like it!

Sacroiliac joint problems

The sacroiliac joint is the roughly triangular bit at

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

the base of the spine where the backbone meets the pelvis. This joint has to stand up to a lot of wear and tear during your lifetime (once again pregnancy rears it’s head!) and can beco

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

me damaged and inflamed, thus pressing on that pesky nerve!

The good news is that these last two can be significantly helped by doing Pilates. I’ll give you more info on this next time

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Advice Pool - Pilates and Sciatica - Part One

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