Advice Pool - Health and Fitness

Recently, everyone in the exercise and fitness industry seems to be talking about core strengthening. Your body’s core—the area around your trunk and pelvis—is where your center of gravity is located. It is the nexus of all y

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

our body’s movements. A strong core gives you:

•Increased protection and bracing for your back.
•Controlled movements, especially when reacting to changes in direction.
•A solid base for all bodily movement

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

.
•Better posture.

The main muscles involved in core stability are the deep muscles of your abdomen and lower back, your buttocks, and the muscles around your hips and pelvis. Core stabilization helps you learn to u

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

e these inner muscles before you start any other movement, so that your spine is braced and your subsequent movements are smoother and more coordinated. Why is Core Stability so Important?

As chiropractors, we tell our pati

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ents over and over again that all parts of their bodies are connected, either directly or indirectly. This connection is called the kinetic chain. Your trunk (core) is where the kinetic chains come together. A weak link in on

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

part of the kinetic chain can lead to pain or injury in another part. Strengthening your core gives greater stability and power to the whole kinetic chain as you move. This leads to a decrease in, or prevention of, lower bac

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

pain; decreased chance of injury; greater strength and power for all activities; and increased confidence form greater strength and better balance. How Can I Increase My Core Strength?

Core stabilization exercises are easy

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

to do, and can be done almost anywhere with little to no equipment. It is more important that core strengthening exercises are done well than that a lot of them are done. It’s a good idea to have a trained professional (chir

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

practor, physical therapist, strength and conditioning specialist, or personal trainer) check to be sure you are using the right muscles during each exercise.

Here are a few simple exercises:

Transversus Abdominis Contracti

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

n:
Contract your belly, imagining that you are pulling your belly button in toward your spine. Hold for 5-10 seconds, and then relax. Repeat until you muscles are fatigued, and then add one additional repetition each day.

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

You can do this exercise at work, while driving, or while in line at the grocery store, and no one will even know.

Bridging:
Lie on your back with your knees bent and feet flat on the floor. Bring your belly button towa

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

rd your spine, then raise you hips off the floor until they are in line with your knees. Hold for 5-10 seconds, and then lower your hips. Repeat until you are fatigued, and then add one repetition each day.

Prone Plank:

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

Lie face down, and then balance yourself on your toes and elbows. Keep your body in a flat line. Try to hold this position for 30-60 seconds.

Quadruped:
Start on your hands and knees. Left one arm out straight, and exte

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

d the opposite leg behind you at the same time. Hold for 2 seconds, and then repeat on the other side. Repeat until fatigued, and then add one repetition per day.

Stability Balls:
Core exercises can be enhanced by perfo

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

rming them on large exercise balls. The challenge of remaining balanced on the ball makes your body use the deep muscles attached to the spine more effectively. It also makes the exercises more fun and lends variety to your w

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

rkout. Other core workout-enhancing tools include: BOSU (Both Sides Up) platforms; wobble and rocker boards; foam rollers; dyna-discs; and foam mats. Try taking your regular weight lifting routine and doing it on one of these

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

apparatuses—you are guaranteed to notice a difference!

Core strengthening should be the most important part of your workout. It should be done at least three times per week. You should focus on replicating the activities you

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

do on a daily basis. Remember, just as a house is only as strong as the foundation it is built on, your body is only as strong as its core.

References:

Berg, Kris, EdD.“Comprehensive Training for Sport: Implications for th

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

Strength and Conditioning Professional.” Strength and Conditioning Journal, Oct. 2006: 10-18.

Brown, Todd D.“Getting to the Core of the Matter.” Strength and Conditioning Journal, Feb. 2006:50-53.

Hanson, Holly.“On a Roll

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

Balls are Becoming Popular Additions to Jazz up Workout.” Milwaukee Journal Sentinel, Aug. 25, 2002:8L.

Kelly, Lance, MPT, ATC.“Strengthening Your Core.” Hughston Health Alert. Available at: www.hughston.com/hha/a_15_2_3.ht

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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